Last reviewed · How we verify
Prasterone (DHEA), Micronized
Prasterone (DHEA) is a naturally occurring steroid hormone precursor that acts as a substrate for the synthesis of androgens and estrogens, modulating hormonal balance and potentially improving ovarian function and fertility.
Prasterone (DHEA) is a naturally occurring steroid hormone precursor that acts as a substrate for the synthesis of androgens and estrogens, modulating hormonal balance and potentially improving ovarian function and fertility. Used for Diminished ovarian reserve in women undergoing assisted reproductive technology (ART), Poor ovarian response to gonadotropin stimulation.
At a glance
| Generic name | Prasterone (DHEA), Micronized |
|---|---|
| Also known as | Intrarosa |
| Sponsor | Hospital Clinic of Barcelona |
| Drug class | Steroid hormone precursor |
| Target | Androgen receptor, estrogen receptor (indirect via metabolic conversion) |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
Prasterone is an endogenous steroid hormone and precursor to both testosterone and estrogen. In micronized form, it enhances bioavailability and is used primarily to improve ovarian reserve and egg quality in women with diminished ovarian function. The hormone works by increasing circulating levels of androgens and estrogens, which may enhance follicle development and oocyte maturation.
Approved indications
- Diminished ovarian reserve in women undergoing assisted reproductive technology (ART)
- Poor ovarian response to gonadotropin stimulation
Common side effects
- Acne
- Hirsutism
- Voice deepening
- Mood changes
- Headache
Key clinical trials
- Vaginal Prasterone In Vaginal Atrophy In Breast Cancer Survivors (PHASE4)
- Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prasterone (DHEA), Micronized CI brief — competitive landscape report
- Prasterone (DHEA), Micronized updates RSS · CI watch RSS
- Hospital Clinic of Barcelona portfolio CI