{"id":"prasterone-dhea-micronized","safety":{"commonSideEffects":[{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Hirsutism"},{"rate":null,"effect":"Voice deepening"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prasterone is an endogenous steroid hormone and precursor to both testosterone and estrogen. In micronized form, it enhances bioavailability and is used primarily to improve ovarian reserve and egg quality in women with diminished ovarian function. The hormone works by increasing circulating levels of androgens and estrogens, which may enhance follicle development and oocyte maturation.","oneSentence":"Prasterone (DHEA) is a naturally occurring steroid hormone precursor that acts as a substrate for the synthesis of androgens and estrogens, modulating hormonal balance and potentially improving ovarian function and fertility.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:06.001Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diminished ovarian reserve in women undergoing assisted reproductive technology (ART)"},{"name":"Poor ovarian response to gonadotropin stimulation"}]},"trialDetails":[{"nctId":"NCT04705883","phase":"PHASE4","title":"Vaginal Prasterone In Vaginal Atrophy In Breast Cancer Survivors","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2020-09-01","conditions":"Vulvar Atrophy, Breast Cancer, Genitourinary Syndrome of Menopause","enrollment":10},{"nctId":"NCT00310791","phase":"PHASE2, PHASE3","title":"Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"2004-04","conditions":"Anorexia Nervosa","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Intrarosa"],"phase":"marketed","status":"active","brandName":"Prasterone (DHEA), Micronized","genericName":"Prasterone (DHEA), Micronized","companyName":"Hospital Clinic of Barcelona","companyId":"hospital-clinic-of-barcelona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prasterone (DHEA) is a naturally occurring steroid hormone precursor that acts as a substrate for the synthesis of androgens and estrogens, modulating hormonal balance and potentially improving ovarian function and fertility. Used for Diminished ovarian reserve in women undergoing assisted reproductive technology (ART), Poor ovarian response to gonadotropin stimulation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}