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Povidone-Iodine Topical Ointment
Povidone-iodine releases iodine that directly kills microorganisms by oxidizing their cellular components and disrupting protein synthesis.
Povidone-iodine releases iodine that directly kills microorganisms by oxidizing their cellular components and disrupting protein synthesis. Used for Minor cuts, wounds, and abrasions, Skin antisepsis and disinfection, Prevention of infection in minor burns and surgical wounds.
At a glance
| Generic name | Povidone-Iodine Topical Ointment |
|---|---|
| Also known as | Profend |
| Sponsor | Marin L. Schweizer, PhD |
| Drug class | Topical antiseptic/antimicrobial |
| Target | Microbial proteins and nucleic acids (non-specific oxidative mechanism) |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Infection Prevention |
| Phase | FDA-approved |
Mechanism of action
Povidone-iodine is a broad-spectrum antimicrobial agent that works through the bactericidal, virucidal, and fungicidal properties of iodine. When applied topically, iodine penetrates microbial cell walls and membranes, oxidizing essential proteins and nucleic acids, thereby rapidly inactivating bacteria, viruses, fungi, and some protozoa. The povidone carrier provides sustained release of iodine and improves stability.
Approved indications
- Minor cuts, wounds, and abrasions
- Skin antisepsis and disinfection
- Prevention of infection in minor burns and surgical wounds
Common side effects
- Local irritation or burning sensation
- Allergic contact dermatitis
- Iodine hypersensitivity reactions
- Staining of skin and clothing
Key clinical trials
- PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study) (PHASE4)
- Mupirocin-Iodophor ICU Decolonization Swap Out Trial (PHASE4)
- Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment (PHASE1)
- Nasal Decolonization of Dialysis Patients Noses (PHASE4)
- Comparison of Duration of CSF Leak in Post Traumatic Patients Managed by Early Lumbar Drain vs Conservative Treatment (NA)
- S. Aureus Decolonization in HPN Patients. (NA)
- Topical Antisepsis in Head and Neck Cancer Surgery
- A Trial Assessing Efficacy of Various Antimicrobial Techniques for Reducing Bacterial Load (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Povidone-Iodine Topical Ointment CI brief — competitive landscape report
- Povidone-Iodine Topical Ointment updates RSS · CI watch RSS
- Marin L. Schweizer, PhD portfolio CI