{"id":"povidone-iodine-topical-ointment","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning sensation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Iodine hypersensitivity reactions"},{"rate":null,"effect":"Staining of skin and clothing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Povidone-iodine is a broad-spectrum antimicrobial agent that works through the bactericidal, virucidal, and fungicidal properties of iodine. When applied topically, iodine penetrates microbial cell walls and membranes, oxidizing essential proteins and nucleic acids, thereby rapidly inactivating bacteria, viruses, fungi, and some protozoa. The povidone carrier provides sustained release of iodine and improves stability.","oneSentence":"Povidone-iodine releases iodine that directly kills microorganisms by oxidizing their cellular components and disrupting protein synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:00.898Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Minor cuts, wounds, and abrasions"},{"name":"Skin antisepsis and disinfection"},{"name":"Prevention of infection in minor burns and surgical wounds"}]},"trialDetails":[{"nctId":"NCT05763602","phase":"PHASE4","title":"PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Loreen Herwaldt","startDate":"2022-09-15","conditions":"Surgical Site Infection","enrollment":2000},{"nctId":"NCT03140423","phase":"PHASE4","title":"Mupirocin-Iodophor ICU Decolonization Swap Out Trial","status":"COMPLETED","sponsor":"Harvard Pilgrim Health Care","startDate":"2017-05-01","conditions":"Staphylococcus Aureus","enrollment":353323},{"nctId":"NCT06339294","phase":"PHASE1","title":"Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment","status":"COMPLETED","sponsor":"Rawalpindi Medical College","startDate":"2023-06-16","conditions":"Otomycosis","enrollment":90},{"nctId":"NCT04210505","phase":"PHASE4","title":"Nasal Decolonization of Dialysis Patients Noses","status":"ACTIVE_NOT_RECRUITING","sponsor":"Marin L. Schweizer, PhD","startDate":"2020-09-29","conditions":"Staphylococcus Aureus Infection","enrollment":302},{"nctId":"NCT05792683","phase":"NA","title":"Comparison of Duration of CSF Leak in Post Traumatic Patients Managed by Early Lumbar Drain vs Conservative Treatment","status":"UNKNOWN","sponsor":"Rawalpindi Medical College","startDate":"2023-02-21","conditions":"CSF Leakage","enrollment":60},{"nctId":"NCT03173053","phase":"NA","title":"S. Aureus Decolonization in HPN Patients.","status":"TERMINATED","sponsor":"Radboud University Medical Center","startDate":"2018-02-08","conditions":"Staphylococcus Aureus, Motility Disorder","enrollment":63},{"nctId":"NCT04721626","phase":"","title":"Topical Antisepsis in Head and Neck Cancer Surgery","status":"COMPLETED","sponsor":"Medical College of Wisconsin","startDate":"2021-01-06","conditions":"Head and Neck Cancer","enrollment":25},{"nctId":"NCT02391077","phase":"PHASE1","title":"A Trial Assessing Efficacy of Various Antimicrobial Techniques for Reducing Bacterial Load","status":"UNKNOWN","sponsor":"Ministry of Health, Rwanda","startDate":"2015-04","conditions":"Disease Due to Gram-positive Bacteria","enrollment":33},{"nctId":"NCT01350713","phase":"NA","title":"The Counter-irritating Efficacy of Topical Povidone-iodine in Thermal Burns","status":"UNKNOWN","sponsor":"Meir Medical Center","startDate":"2011-07","conditions":"Skin Burns","enrollment":280}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Profend"],"phase":"marketed","status":"active","brandName":"Povidone-Iodine Topical Ointment","genericName":"Povidone-Iodine Topical Ointment","companyName":"Marin L. Schweizer, PhD","companyId":"marin-l-schweizer-phd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Povidone-iodine releases iodine that directly kills microorganisms by oxidizing their cellular components and disrupting protein synthesis. Used for Minor cuts, wounds, and abrasions, Skin antisepsis and disinfection, Prevention of infection in minor burns and surgical wounds.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}