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Potassium nitrate and sodium fluoride
Potassium nitrate and sodium fluoride work together to desensitize dental nerves and strengthen tooth enamel by blocking pain transmission and remineralizing tooth structure.
Potassium nitrate and sodium fluoride work together to desensitize dental nerves and strengthen tooth enamel by blocking pain transmission and remineralizing tooth structure. Used for Dentin hypersensitivity / tooth sensitivity, Enamel remineralization and caries prevention.
At a glance
| Generic name | Potassium nitrate and sodium fluoride |
|---|---|
| Also known as | GC |
| Sponsor | Universidade Federal do Para |
| Drug class | Desensitizing agent / Topical fluoride |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Oral Health |
| Phase | FDA-approved |
Mechanism of action
Potassium nitrate penetrates the tooth structure and depolarizes sensory C-fibers, blocking pain signal transmission to the nerve. Sodium fluoride promotes remineralization of enamel and dentin, strengthening the tooth surface and reducing sensitivity. Together, these agents provide both symptomatic relief of dental hypersensitivity and structural reinforcement of vulnerable tooth surfaces.
Approved indications
- Dentin hypersensitivity / tooth sensitivity
- Enamel remineralization and caries prevention
Common side effects
- Mild gingival irritation
- Temporary tooth discoloration
- Allergic reaction (rare)
Key clinical trials
- Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste (PHASE3)
- Bioadhesive Film of Acmella Oleracea (Jambu) in the Reduction of Post-bleaching Dental Sensitivity Caused by Bleaching With 35% Hydrogen Peroxide. (PHASE3)
- Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste (NA)
- A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries (NA)
- Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization (NA)
- Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity (PHASE1)
- Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth (NA)
- Evaluation of In-office Bleaching-induced Sensitivity With 2 or 7 Days Interval Between Sessions (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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