{"id":"potassium-nitrate-and-sodium-fluoride","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild gingival irritation"},{"rate":null,"effect":"Temporary tooth discoloration"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":null,"_dailymed":{"setId":"a2f9d58b-671b-4427-a971-1fceff5f2323","title":"SENSODYNE PRONAMEL INTENSIVE ENAMEL REPAIR CLEAN MINT (POTASSIUM NITRATE AND SODIUM FLUORIDE) PASTE SENSODYNE PRONAMEL INTENSIVE ENAMEL REPAIR EXTRA FRESH (POTASSIUM NITRATE AND SODIUM FLUORIDE) PASTE SENSODYNE PRONAMEL INTENSIVE ENAMEL REPAIR WHITENING (POTASSIUM NITRATE AND SODIUM FLUORIDE) PASTE [HALEON US HOLDINGS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Potassium nitrate penetrates the tooth structure and depolarizes sensory C-fibers, blocking pain signal transmission to the nerve. Sodium fluoride promotes remineralization of enamel and dentin, strengthening the tooth surface and reducing sensitivity. Together, these agents provide both symptomatic relief of dental hypersensitivity and structural reinforcement of vulnerable tooth surfaces.","oneSentence":"Potassium nitrate and sodium fluoride work together to desensitize dental nerves and strengthen tooth enamel by blocking pain transmission and remineralizing tooth structure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:59:36.915Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dentin hypersensitivity / tooth sensitivity"},{"name":"Enamel remineralization and caries prevention"}]},"trialDetails":[{"nctId":"NCT06956599","phase":"PHASE3","title":"Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-05-10","conditions":"Dentin Hypersensitivity","enrollment":80},{"nctId":"NCT07478640","phase":"PHASE3","title":"Bioadhesive Film of Acmella Oleracea (Jambu) 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Sergipe","startDate":"2018-05-26","conditions":"Medicaments Substances in Therapeutic Use","enrollment":75},{"nctId":"NCT04305483","phase":"NA","title":"Evaluation of the Color Change of the Laser and Chemical Vital Whitening Method in the Teeth","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2013-12-01","conditions":"Color; Change Teeth, Posteruptive","enrollment":40},{"nctId":"NCT04156152","phase":"NA","title":"Effectiveness of the Use of Desensitizing Dentifrices Based on Nanocrystals of Hydroxyapatite / 5% Potassium Nitrate / 1450ppm Sodium Monofluorophosphate and Potassium Nitrate 5% / 1426ppm Sodium Floride in the Treatment of Dentine Hypersensitivity. 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Characterisation of Immunological Effects and Safety of Active O2","status":"COMPLETED","sponsor":"Adelholzener Alpenquellen GmbH","startDate":"2012-01","conditions":"Healthy","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GC"],"phase":"marketed","status":"active","brandName":"Potassium nitrate and sodium fluoride","genericName":"Potassium nitrate and sodium fluoride","companyName":"Universidade Federal do Para","companyId":"universidade-federal-do-para","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Potassium nitrate and 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Used for Dentin hypersensitivity / tooth sensitivity, Enamel remineralization and caries prevention.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}