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Potassium Nitrate 2%
Potassium nitrate acts as a nitrate donor that releases nitric oxide, which causes vasodilation and reduces dentin hypersensitivity by blocking neural transmission in exposed dentinal tubules.
Potassium nitrate acts as a nitrate donor that releases nitric oxide, which causes vasodilation and reduces dentin hypersensitivity by blocking neural transmission in exposed dentinal tubules. Used for Dentin hypersensitivity, Tooth sensitivity to thermal, chemical, and tactile stimuli.
At a glance
| Generic name | Potassium Nitrate 2% |
|---|---|
| Also known as | Desensibilize KF |
| Sponsor | Federal University of Uberlandia |
| Drug class | Desensitizing agent |
| Target | Nitric oxide pathway; sensory nerve fibers (TRPV1) |
| Modality | Small molecule |
| Therapeutic area | Dentistry |
| Phase | FDA-approved |
Mechanism of action
Potassium nitrate is a salt that dissociates to provide nitrate ions, which are converted to nitric oxide in tissues. Nitric oxide promotes smooth muscle relaxation in blood vessels, causing vasodilation. In dental applications, potassium nitrate desensitizes teeth by depolarizing nerve fibers and blocking the transmission of pain signals from the dentin to the pulp.
Approved indications
- Dentin hypersensitivity
- Tooth sensitivity to thermal, chemical, and tactile stimuli
Common side effects
- Mild gum irritation
- Temporary tooth discoloration
- Allergic reaction (rare)
Key clinical trials
- Bioadhesive Film of Acmella Oleracea (Jambu) in the Reduction of Post-bleaching Dental Sensitivity Caused by Bleaching With 35% Hydrogen Peroxide. (PHASE3)
- Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice (PHASE3)
- A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes (NA)
- Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals (NA)
- A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries (NA)
- SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial (PHASE2)
- Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization (NA)
- Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |