{"id":"potassium-nitrate-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild gum irritation"},{"rate":null,"effect":"Temporary tooth discoloration"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":null,"_dailymed":{"setId":"e5ebf7aa-fbe5-45b1-e053-2a95a90a5cbf","title":"GRAFCO SILVER NITRATE (75% SILVER NITRATE, 25% POTASSIUM NITRATE) STICK [HF ACQUISITION CO LLC, DBA HEALTHFIRST]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Potassium nitrate is a salt that dissociates to provide nitrate ions, which are converted to nitric oxide in tissues. Nitric oxide promotes smooth muscle relaxation in blood vessels, causing vasodilation. In dental applications, potassium nitrate desensitizes teeth by depolarizing nerve fibers and blocking the transmission of pain signals from the dentin to the pulp.","oneSentence":"Potassium nitrate acts as a nitrate donor that releases nitric oxide, which causes vasodilation and reduces dentin hypersensitivity by blocking neural transmission in exposed dentinal tubules.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T06:22:16.264Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dentin hypersensitivity"},{"name":"Tooth sensitivity to thermal, chemical, and tactile stimuli"}]},"trialDetails":[{"nctId":"NCT07478640","phase":"PHASE3","title":"Bioadhesive Film of Acmella Oleracea (Jambu) in the Reduction of Post-bleaching Dental Sensitivity Caused by Bleaching With 35% Hydrogen Peroxide.","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-04-01","conditions":"Tooth Sensitivity, Teeth Whitening","enrollment":72},{"nctId":"NCT07215767","phase":"PHASE3","title":"Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice","status":"RECRUITING","sponsor":"HALEON","startDate":"2025-09-16","conditions":"Dentin Hypersensitivity","enrollment":850},{"nctId":"NCT07297732","phase":"NA","title":"A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes","status":"RECRUITING","sponsor":"HALEON","startDate":"2025-12-15","conditions":"Dentin Hypersensitivity","enrollment":105},{"nctId":"NCT07172425","phase":"NA","title":"Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals","status":"RECRUITING","sponsor":"Queen Mary University of London","startDate":"2025-10-15","conditions":"Healthy Volunteers, Nitric Oxide, Vascular Function","enrollment":30},{"nctId":"NCT06949072","phase":"NA","title":"A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-04-28","conditions":"Dental Caries","enrollment":47},{"nctId":"NCT05138575","phase":"PHASE2","title":"SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2022-01-24","conditions":"Heart Failure With Preserved Ejection Fraction","enrollment":53},{"nctId":"NCT07056855","phase":"NA","title":"Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-07-10","conditions":"Dentine Hypersensitivity","enrollment":48},{"nctId":"NCT07027566","phase":"PHASE1","title":"Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity","status":"NOT_YET_RECRUITING","sponsor":"Universidade Federal do Para","startDate":"2025-07-25","conditions":"Dentin Sensitivity","enrollment":75},{"nctId":"NCT06971783","phase":"NA","title":"Effect of an Experimental Gel Based on Acmella Oleracea Extract Associated or Not With Fluoride on Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-08-20","conditions":"Dentin Desensitizers, Non-carious Cervical Lesions, Dentin Hypersensitivity","enrollment":100},{"nctId":"NCT02797184","phase":"PHASE1, PHASE2","title":"Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2017-10-31","conditions":"Heart Failure","enrollment":42},{"nctId":"NCT06242444","phase":"NA","title":"An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-02-26","conditions":"Tooth Erosion","enrollment":33},{"nctId":"NCT06896565","phase":"NA","title":"Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-06-01","conditions":"Molar Incisor Hypomineralisation","enrollment":48},{"nctId":"NCT06394557","phase":"NA","title":"Evaluation of In-office Bleaching-induced Sensitivity With 2 or 7 Days Interval Between Sessions","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universidade Federal Fluminense","startDate":"2023-08-14","conditions":"Tooth Sensitivity","enrollment":47},{"nctId":"NCT06871709","phase":"NA","title":"Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-05-30","conditions":"Vital Pulp Therapies, Pulpotomy, Pulp Disease, Dental","enrollment":50},{"nctId":"NCT06627790","phase":"PHASE3","title":"Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxalate Mouthwash in Dentinal Hypersensitivity","status":"RECRUITING","sponsor":"Dr. D. 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Patil Dental College & Hospital","startDate":"2025-02-25","conditions":"Dentin Hypersensitivity","enrollment":40},{"nctId":"NCT06746558","phase":"NA","title":"Potassium Nitrate Gel and Diode Laser for Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"University of Modena and Reggio Emilia","startDate":"2023-01-07","conditions":"Hypersensitivity Dentin","enrollment":12},{"nctId":"NCT05243745","phase":"NA","title":"Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-02-28","conditions":"Dentin Sensitivity","enrollment":120},{"nctId":"NCT03259165","phase":"PHASE2","title":"Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial","status":"TERMINATED","sponsor":"Indiana University","startDate":"2017-12-14","conditions":"Heart Failure, Heart Failure Acute, Acute Cardiac Failure","enrollment":52},{"nctId":"NCT06358911","phase":"PHASE4","title":"A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-11-13","conditions":"Tooth Hypersensitivity","enrollment":60},{"nctId":"NCT05459558","phase":"NA","title":"Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-09-15","conditions":"Oral Hygiene","enrollment":280},{"nctId":"NCT06180707","phase":"PHASE3","title":"Pregabalin Gel in Reducing Post-operative Tooth Sensitivity Surgery Caused by Bleaching With 35% Hydrogen Peroxide","status":"UNKNOWN","sponsor":"Universidade Federal do Para","startDate":"2024-01-05","conditions":"Tooth Bleaching, Sensitivity, Tooth","enrollment":75},{"nctId":"NCT04590040","phase":"NA","title":"Trial of Nano-hydroxyapatite-Containing Toothpastes 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Sensitivity","enrollment":123},{"nctId":"NCT04305483","phase":"NA","title":"Evaluation of the Color Change of the Laser and Chemical Vital Whitening Method in the Teeth","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2013-12-01","conditions":"Color; Change Teeth, Posteruptive","enrollment":40},{"nctId":"NCT03362697","phase":"NA","title":"Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women","status":"COMPLETED","sponsor":"Innovacion y Desarrollo de Estrategias en Salud","startDate":"2017-12-15","conditions":"Urinary Tract Infection in Pregnancy","enrollment":150},{"nctId":"NCT02916615","phase":"NA","title":"Effects of Nitrate in Vegetables on Blood Pressure in Subjects With Prehypertension","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2016-01","conditions":"Hypertension, Cardiovascular Disease","enrollment":225},{"nctId":"NCT03267511","phase":"PHASE2","title":"A Study to Investigate the Stain and Plaque Removal 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Supplementation and Crossfit Athletes","status":"COMPLETED","sponsor":"Florida State University","startDate":"2014-08","conditions":"Performance","enrollment":12},{"nctId":"NCT01115452","phase":"PHASE2","title":"Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-09","conditions":"Dentine Hypersensitivity","enrollment":32},{"nctId":"NCT01426360","phase":"NA","title":"Instant and Lasting Relief Effects of Strontium Chloride/Potassium Nitrate Dentifrice on Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2011-09","conditions":"Dentine Hypersensitivity","enrollment":79}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Desensibilize KF"],"phase":"marketed","status":"active","brandName":"Potassium Nitrate 2%","genericName":"Potassium Nitrate 2%","companyName":"Federal University of Uberlandia","companyId":"federal-university-of-uberlandia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Potassium nitrate acts as a nitrate donor that releases nitric oxide, which causes vasodilation and reduces dentin hypersensitivity by blocking neural transmission in exposed dentinal tubules. Used for Dentin hypersensitivity, Tooth sensitivity to thermal, chemical, and tactile stimuli.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}