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potassium chloride replacement
Potassium chloride replaces depleted potassium ions to restore normal serum potassium levels and maintain cellular and cardiac function.
Potassium chloride replaces depleted potassium ions to restore normal serum potassium levels and maintain cellular and cardiac function. Used for Hypokalemia (potassium deficiency) prevention and treatment, Potassium supplementation in patients at risk of hypokalemia due to diuretics, corticosteroids, or other medications.
At a glance
| Generic name | potassium chloride replacement |
|---|---|
| Sponsor | Baptist Health South Florida |
| Drug class | Electrolyte replacement / mineral supplement |
| Target | Potassium ion (K+) |
| Modality | Small molecule |
| Therapeutic area | Electrolyte management / General medicine |
| Phase | FDA-approved |
Mechanism of action
Potassium is an essential electrolyte required for proper nerve conduction, muscle contraction, and cardiac rhythm. Potassium chloride replacement therapy directly replenishes intracellular and extracellular potassium stores in patients with hypokalemia (low serum potassium). This restores the normal potassium gradient across cell membranes, which is critical for maintaining normal electrical activity in the heart and skeletal muscles.
Approved indications
- Hypokalemia (potassium deficiency) prevention and treatment
- Potassium supplementation in patients at risk of hypokalemia due to diuretics, corticosteroids, or other medications
Common side effects
- Gastrointestinal irritation (nausea, vomiting, abdominal discomfort)
- Hyperkalemia (elevated serum potassium) with overdose
- Diarrhea
Key clinical trials
- A Community Health Worker-Led LSSS Intervention in Bangladesh (NA)
- CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS (PHASE4)
- Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator (PHASE4)
- Liberation From Acute Dialysis (NA)
- Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Immunoglobulin Stopping or Extension (Stop Ig) (PHASE2, PHASE3)
- Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT) (PHASE2, PHASE3)
- Timing of Renal Replacement Therapy in the Critically Ill Patients
- Registry of Pre-mixed Solutions in Critically Ill Patients on the Continuous Renal Replacement Therapy
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- potassium chloride replacement CI brief — competitive landscape report
- potassium chloride replacement updates RSS · CI watch RSS
- Baptist Health South Florida portfolio CI