{"id":"potassium-chloride-replacement","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal irritation (nausea, vomiting, abdominal discomfort)"},{"rate":null,"effect":"Hyperkalemia (elevated serum potassium) with overdose"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL1200731","moleculeType":"Small molecule","molecularWeight":"74.55"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Potassium is an essential electrolyte required for proper nerve conduction, muscle contraction, and cardiac rhythm. Potassium chloride replacement therapy directly replenishes intracellular and extracellular potassium stores in patients with hypokalemia (low serum potassium). This restores the normal potassium gradient across cell membranes, which is critical for maintaining normal electrical activity in the heart and skeletal muscles.","oneSentence":"Potassium chloride replaces depleted potassium ions to restore normal serum potassium levels and maintain cellular and cardiac function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:57.805Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypokalemia (potassium deficiency) prevention and treatment"},{"name":"Potassium supplementation in patients at risk of hypokalemia due to diuretics, corticosteroids, or other medications"}]},"trialDetails":[{"nctId":"NCT05425030","phase":"NA","title":"A Community Health Worker-Led LSSS Intervention in Bangladesh","status":"COMPLETED","sponsor":"Stanford University","startDate":"2023-01-26","conditions":"Blood Pressure, Hypertension","enrollment":618},{"nctId":"NCT07189091","phase":"PHASE4","title":"CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS","status":"RECRUITING","sponsor":"University Hospital, Antwerp","startDate":"2025-10-07","conditions":"Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance","enrollment":640},{"nctId":"NCT06696235","phase":"PHASE4","title":"Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator","status":"RECRUITING","sponsor":"Samsung Medical Center","startDate":"2024-12-31","conditions":"Cardiogenic Shock, Acute Kidney Injury","enrollment":408},{"nctId":"NCT04218370","phase":"NA","title":"Liberation From Acute Dialysis","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2020-01-23","conditions":"Acute Kidney Injury, Kidney; 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Used for Hypokalemia (potassium deficiency) prevention and treatment, Potassium supplementation in patients at risk of hypokalemia due to diuretics, corticosteroids, or other medications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}