Last reviewed 2026-04-22 · How we verify

Postoperative pain management with metamizole

Metamizole inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain and fever through central and peripheral analgesic and antipyretic effects.

Metamizole inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain and fever through central and peripheral analgesic and antipyretic effects. Used for Postoperative pain management.

At a glance

Mechanism of action

Metamizole (dipyrone) is a non-selective inhibitor of cyclooxygenase (COX) enzymes, which decreases prostaglandin production in both the central nervous system and peripheral tissues. This dual action reduces pain signal transmission and lowers the hypothalamic pain set point, making it effective for acute postoperative pain management. The drug also has mild anti-inflammatory properties that contribute to its analgesic efficacy.

Approved indications

• Postoperative pain management

Common side effects

• Agranulocytosis
• Anaphylaxis
• Gastrointestinal upset
• Rash

Key clinical trials

• Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
• Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
• Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
• AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair (NA)
• The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery
• Treatment of Pelvic Ring Fractures in the Elderly (NA)
• Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS (NA)
• Comparison of Two Pain-treatment Techniques After Cesarean Section (PHASE4)

Primary sources

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