{"id":"postoperative-pain-management-with-metamizole","safety":{"commonSideEffects":[{"rate":null,"effect":"Agranulocytosis"},{"rate":null,"effect":"Anaphylaxis"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metamizole (dipyrone) is a non-selective inhibitor of cyclooxygenase (COX) enzymes, which decreases prostaglandin production in both the central nervous system and peripheral tissues. This dual action reduces pain signal transmission and lowers the hypothalamic pain set point, making it effective for acute postoperative pain management. The drug also has mild anti-inflammatory properties that contribute to its analgesic efficacy.","oneSentence":"Metamizole inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain and fever through central and peripheral analgesic and antipyretic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:03.782Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT06878014","phase":"PHASE4","title":"Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery","status":"RECRUITING","sponsor":"Medical University of Silesia","startDate":"2025-03-04","conditions":"Analgesics, Opioid, Anesthesia, Spinal, Total Hip Replacement","enrollment":120},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06609993","phase":"NA","title":"AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair","status":"COMPLETED","sponsor":"Michał Stasiowski","startDate":"2017-12-12","conditions":"Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":75},{"nctId":"NCT05591105","phase":"","title":"The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery","status":"COMPLETED","sponsor":"Tiva Group","startDate":"2023-06-15","conditions":"Pharmacological Action, Post Operative Pain, Opioid Use","enrollment":64},{"nctId":"NCT02590783","phase":"NA","title":"Treatment of Pelvic Ring Fractures in the Elderly","status":"TERMINATED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2017-10-17","conditions":"Pelvic Pain","enrollment":88},{"nctId":"NCT03389243","phase":"NA","title":"Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2018-01-15","conditions":"Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":165},{"nctId":"NCT02804126","phase":"PHASE4","title":"Comparison of Two Pain-treatment Techniques After Cesarean Section","status":"COMPLETED","sponsor":"Michał Borys","startDate":"2017-06-01","conditions":"Cesarean Section, Pain Management, Neuropathic Pain","enrollment":232},{"nctId":"NCT03404908","phase":"PHASE4","title":"TAP vs QLB in Patients After Cesarean Delivery","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-02-07","conditions":"Cesarean Section, Postoperative Pain","enrollment":105},{"nctId":"NCT04939545","phase":"PHASE3","title":"Study of Postoperative ICC Analgesia","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2021-12-15","conditions":"Postoperative Analgesia","enrollment":32},{"nctId":"NCT02689024","phase":"PHASE4","title":"Delirium in Elderly Patients With Trauma of the Hip","status":"TERMINATED","sponsor":"Academisch Medisch Centrum - 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Randomized Study.","status":"COMPLETED","sponsor":"Cuiaba University","startDate":"2012-04","conditions":"To Evaluate Clinical Results, Insulin Resistance and Inflammatory Response to Trauma in Morbidly Obese Patients","enrollment":20},{"nctId":"NCT01858402","phase":"PHASE2","title":"Paracetamol Versus Dipyrone After Pediatric Lower Abdominal Surgery in Children With Spinal Anesthesia","status":"COMPLETED","sponsor":"Baskent University","startDate":"2009-12","conditions":"Other Acute Postoperative Pain","enrollment":2},{"nctId":"NCT01501565","phase":"PHASE4","title":"Analgesic Efficacy of Ultrasound-guided Transverse-abdominal Plain Blockade in Urological Surgery","status":"COMPLETED","sponsor":"Fundacio Puigvert","startDate":"2011-12","conditions":"Postoperative Pain","enrollment":141}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":70,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Postoperative pain management with metamizole","genericName":"Postoperative pain management with metamizole","companyName":"Medical University of Silesia","companyId":"medical-university-of-silesia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metamizole inhibits prostaglandin synthesis by blocking cyclooxygenase enzymes, reducing pain and fever through central and peripheral analgesic and antipyretic effects. Used for Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}