Last reviewed 2026-04-22 · How we verify

Postop oral orphenadrine

Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and pain.

Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and pain. Used for Postoperative muscle pain and spasm.

At a glance

Mechanism of action

Orphenadrine works by antagonizing muscarinic cholinergic receptors in the central and peripheral nervous system, which reduces the transmission of pain signals and decreases involuntary muscle contractions. It also has mild antihistamine and local anesthetic properties. In the postoperative setting, it is used to manage acute muscle pain and spasticity following surgery.

Approved indications

• Postoperative muscle pain and spasm

Common side effects

• Dry mouth
• Dizziness
• Drowsiness
• Blurred vision
• Tachycardia
• Urinary retention

Key clinical trials

• Comparison of Post-Operative Analgesia After Percutaneous Nephrolithotomy. (PHASE4)
• Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee (PHASE4)
• Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery (PHASE4)
• Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Postop oral orphenadrine CI brief — competitive landscape report
• Postop oral orphenadrine updates RSS · CI watch RSS
• AdventHealth portfolio CI