{"id":"postop-oral-orphenadrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Urinary retention"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Orphenadrine works by antagonizing muscarinic cholinergic receptors in the central and peripheral nervous system, which reduces the transmission of pain signals and decreases involuntary muscle contractions. It also has mild antihistamine and local anesthetic properties. In the postoperative setting, it is used to manage acute muscle pain and spasticity following surgery.","oneSentence":"Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:36:23.685Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative muscle pain and spasm"}]},"trialDetails":[{"nctId":"NCT04835116","phase":"PHASE4","title":"Comparison of Post-Operative Analgesia After Percutaneous Nephrolithotomy.","status":"COMPLETED","sponsor":"Armed Forces Institute of Urology, Rawalpindi","startDate":"2019-04-11","conditions":"Pain, Postoperative Pain","enrollment":68},{"nctId":"NCT02449369","phase":"PHASE4","title":"Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee","status":"COMPLETED","sponsor":"AdventHealth","startDate":"2015-04","conditions":"Unilateral Knee Arthroplasty","enrollment":180},{"nctId":"NCT02958566","phase":"PHASE4","title":"Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Illinois College of Medicine at Peoria","startDate":"2017-01","conditions":"Colon Cancer, Colon Diverticulosis, Colonic Neoplasms","enrollment":80},{"nctId":"NCT02445599","phase":"PHASE4","title":"Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain","status":"COMPLETED","sponsor":"University of Debrecen","startDate":"2014-04","conditions":"Pain, Inadequate or Impaired Respiratory Function","enrollment":3}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Norflex"],"phase":"marketed","status":"active","brandName":"Postop oral orphenadrine","genericName":"Postop oral orphenadrine","companyName":"AdventHealth","companyId":"adventhealth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and pain. Used for Postoperative muscle pain and spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}