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polyethylene glycol, senna
Polyethylene glycol and senna work together as an osmotic laxative and stimulant laxative to increase stool water content and promote bowel motility for constipation relief.
Polyethylene glycol and senna work together as an osmotic laxative and stimulant laxative to increase stool water content and promote bowel motility for constipation relief. Used for Constipation in pediatric patients, Bowel preparation in children.
At a glance
| Generic name | polyethylene glycol, senna |
|---|---|
| Also known as | Miralax, Senna |
| Sponsor | Children's Hospital of Philadelphia |
| Drug class | Osmotic and stimulant laxative combination |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Polyethylene glycol (PEG) is an osmotic agent that draws water into the intestinal lumen, softening stool and increasing its bulk. Senna is a natural stimulant laxative derived from plant sennosides that directly stimulate colonic muscle contractions. Together, they provide both osmotic and mechanical effects to promote bowel evacuation.
Approved indications
- Constipation in pediatric patients
- Bowel preparation in children
Common side effects
- Abdominal cramping
- Nausea
- Diarrhea
- Bloating
Key clinical trials
- Whatsapp Based Patient Education to Improve Bowel Preparation for Colonoscopy (NA)
- PEG3350 vs Senna After Urogyn Surgery (PHASE4)
- Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation (PHASE4)
- Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids (PHASE4)
- Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients (PHASE4)
- Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure (NA)
- Methylnaltrexone Use for Opioid-induced Postoperative Constipation (PHASE4)
- Bowel Preparation for Colonoscopy in Children (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- polyethylene glycol, senna CI brief — competitive landscape report
- polyethylene glycol, senna updates RSS · CI watch RSS
- Children's Hospital of Philadelphia portfolio CI