{"id":"polyethylene-glycol-senna","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Bloating"}]},"_chembl":{"chemblId":"CHEMBL1201478","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polyethylene glycol (PEG) is an osmotic agent that draws water into the intestinal lumen, softening stool and increasing its bulk. Senna is a natural stimulant laxative derived from plant sennosides that directly stimulate colonic muscle contractions. Together, they provide both osmotic and mechanical effects to promote bowel evacuation.","oneSentence":"Polyethylene glycol and senna work together as an osmotic laxative and stimulant laxative to increase stool water content and promote bowel motility for constipation relief.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:01:46.003Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation in pediatric patients"},{"name":"Bowel preparation in children"}]},"trialDetails":[{"nctId":"NCT07426133","phase":"NA","title":"Whatsapp Based Patient Education to Improve Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Shaukat Khanum Memorial Cancer Hospital & Research Centre","startDate":"2025-03-23","conditions":"Assessing Bowel Preparation Quality","enrollment":110},{"nctId":"NCT06825260","phase":"PHASE4","title":"PEG3350 vs Senna After Urogyn Surgery","status":"RECRUITING","sponsor":"St. Joseph's Health, New York","startDate":"2025-04-23","conditions":"Obstructive Defecation Syndrome, Postoperative Constipation","enrollment":254},{"nctId":"NCT03148002","phase":"PHASE4","title":"Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation","status":"COMPLETED","sponsor":"Nova Scotia Health Authority","startDate":"2017-07-07","conditions":"Constipation, Peritoneal Dialysis Complication","enrollment":25},{"nctId":"NCT02977286","phase":"PHASE4","title":"Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids","status":"TERMINATED","sponsor":"Tufts Medical Center","startDate":"2017-01-01","conditions":"Constipation","enrollment":12},{"nctId":"NCT01189409","phase":"PHASE4","title":"Polyethylene Glycol (PEG) Versus Sennosides Study in Opioid-Induced Constipation in Cancer Patients","status":"TERMINATED","sponsor":"British Columbia Cancer Agency","startDate":"2010-06","conditions":"Constipation, Cancer","enrollment":70},{"nctId":"NCT02481219","phase":"NA","title":"Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure","status":"COMPLETED","sponsor":"Medtronic - MITG","startDate":"2015-05","conditions":"Colorectal Cancer Screening","enrollment":122},{"nctId":"NCT01773096","phase":"PHASE4","title":"Methylnaltrexone Use for Opioid-induced Postoperative Constipation","status":"COMPLETED","sponsor":"Shriners Hospitals for Children","startDate":"2013-05","conditions":"Constipation","enrollment":60},{"nctId":"NCT01140295","phase":"PHASE4","title":"Bowel Preparation for Colonoscopy in Children","status":"TERMINATED","sponsor":"Children's Hospital of Philadelphia","startDate":"2010-09","conditions":"Colonoscopy Preparation","enrollment":33},{"nctId":"NCT01531140","phase":"PHASE4","title":"PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2010-11","conditions":"Colonoscopy Preparation","enrollment":240}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"MALIGNANT NEOPLASM PROGRESSION"}],"_approvalHistory":[],"publicationCount":83,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Miralax","Senna"],"phase":"marketed","status":"active","brandName":"polyethylene glycol, senna","genericName":"polyethylene glycol, senna","companyName":"Children's Hospital of Philadelphia","companyId":"children-s-hospital-of-philadelphia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polyethylene glycol and senna work together as an osmotic laxative and stimulant laxative to increase stool water content and promote bowel motility for constipation relief. Used for Constipation in pediatric patients, Bowel preparation in children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}