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Polyethylene Glycol morning
Polyethylene Glycol morning is a Osmotic laxative Small molecule drug developed by Cleveland Clinic Florida. It is currently in Phase 3 development for Bowel preparation prior to colonoscopy or other GI procedures, Constipation management. Also known as: Golytely.
Polyethylene glycol acts as an osmotic laxative that draws water into the intestinal lumen to promote bowel movements.
Polyethylene glycol acts as an osmotic laxative that draws water into the intestinal lumen to promote bowel movements. Used for Bowel preparation prior to colonoscopy or other GI procedures, Constipation management.
At a glance
| Generic name | Polyethylene Glycol morning |
|---|---|
| Also known as | Golytely |
| Sponsor | Cleveland Clinic Florida |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
PEG is a non-absorbable polymer that creates an osmotic gradient in the gastrointestinal tract, increasing stool water content and promoting intestinal motility. This mechanism facilitates bowel evacuation without being systemically absorbed, making it suitable for bowel preparation and constipation management.
Approved indications
- Bowel preparation prior to colonoscopy or other GI procedures
- Constipation management
Common side effects
- Nausea
- Abdominal bloating
- Abdominal cramping
- Vomiting
- Diarrhea
Key clinical trials
- Pre-packaged Low-residue Diet for Bowel Preparation in Patients With Inflammatory Bowel Disease (NA)
- Efficacy and Safety of mAnnitol in Bowel Preparation During Elective Colonoscopy and Comparison With Moviprep® (PHASE2, PHASE3)
- PEG-Asc Vs. SPMC for Bowel Preparation in Capsule-based Procedures (NA)
- Comparative Study Between Colonoscopy Bowel Preparation With Clear Liquids, With and Without Two Servings of High Energy Nutritional Supplement (NA)
- Simplified Bowel Preparation Versus Standard Bowel Preparation Before Capsule Endoscopy in Patients With Crohn's Disease (NA)
- Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients (NA)
- Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism (NA)
- A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Polyethylene Glycol morning CI brief — competitive landscape report
- Polyethylene Glycol morning updates RSS · CI watch RSS
- Cleveland Clinic Florida portfolio CI
Frequently asked questions about Polyethylene Glycol morning
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Related
- Drug class: All Osmotic laxative drugs
- Manufacturer: Cleveland Clinic Florida — full pipeline
- Therapeutic area: All drugs in Gastroenterology
- Indication: Drugs for Bowel preparation prior to colonoscopy or other GI procedures
- Indication: Drugs for Constipation management
- Also known as: Golytely
- Compare: Polyethylene Glycol morning vs similar drugs
- Pricing: Polyethylene Glycol morning cost, discount & access