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Plain bupivacaine
Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.
Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local infiltration anesthesia, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | Plain bupivacaine |
|---|---|
| Also known as | Bupivacaine Hydrochloride |
| Sponsor | Fayoum University Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes. This prevents depolarization and the generation of action potentials, thereby blocking nerve conduction in a dose-dependent manner. The drug is commonly used for infiltration anesthesia, nerve blocks, and epidural/spinal anesthesia due to its prolonged duration of action.
Approved indications
- Local infiltration anesthesia
- Peripheral nerve blocks
- Epidural anesthesia
- Spinal anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular toxicity (hypotension, arrhythmias)
- Local tissue irritation or pain at injection site
- Allergic reactions (rare with amide local anesthetics)
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine (PHASE3)
- Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery (PHASE3)
- TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant (PHASE4)
- Bupivacaine Liposome Versus Bupivacaine for Ultrasound-Guided Suprascapular Nerve Combined With Axillary Nerve Block in Analgesia After Arthroscopic Shoulder Surgery (PHASE4)
- Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy (PHASE2)
- Comparing the Efficacy of Ultrasound Guided Erector Spinae Plane Block, Ultrasound Guided Caudal Block, and Local Infiltration for Postoperative Pain Control in Pediatric Patients Undergoing Unilateral Inguinal Hernia Repair as a Day-Case Surgeries: A Randomized Controlled Trial (NA)
- Exparel Injection for Postoperative Orbital Pain (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Plain bupivacaine CI brief — competitive landscape report
- Plain bupivacaine updates RSS · CI watch RSS
- Fayoum University Hospital portfolio CI