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Placebo oral tablet preoperative administration
Placebo oral tablet preoperative administration is a Small molecule drug developed by University of Roma La Sapienza. It is currently FDA-approved for Preoperative anxiety reduction, Preoperative stress response modulation. Also known as: GROUP C.
A placebo tablet produces therapeutic effects through psychological and psychophysiological mechanisms, including expectancy-driven modulation of pain perception, anxiety, and stress responses.
A placebo tablet produces therapeutic effects through psychological and psychophysiological mechanisms, including expectancy-driven modulation of pain perception, anxiety, and stress responses. Used for Preoperative anxiety reduction, Preoperative stress response modulation.
At a glance
| Generic name | Placebo oral tablet preoperative administration |
|---|---|
| Also known as | GROUP C |
| Sponsor | University of Roma La Sapienza |
| Modality | Small molecule |
| Therapeutic area | Perioperative Medicine / Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Placebo effects operate via multiple pathways: expectancy and conditioning activate endogenous opioid and dopaminergic systems, reduce anticipatory anxiety, and modulate autonomic nervous system activity. In the preoperative context, placebo administration can reduce preoperative anxiety, lower cortisol levels, and potentially improve postoperative outcomes through reduced stress-induced physiological responses. These effects are measurable and distinct from inert administration, though the magnitude varies by individual and clinical context.
Approved indications
- Preoperative anxiety reduction
- Preoperative stress response modulation
Common side effects
Key clinical trials
- Management of Pain in Lumbar Arthrodesis (PHASE4)
- NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty (NA)
- Phase III Study of Envafolimab Versus Placebo Plus Chemotherapy in Resectable Stage III NSCLC (PHASE3)
- Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study (PHASE4)
- Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial (PHASE3)
- The Effects of a 6-week Pre-operative Administration of a Microbiome Modulator "WellBiome" Versus Placebo on Cardiac Surgical Outcomes and NHS Cost Savings. (NA)
- Effect of Pregabalin on the Postoperative Analgesia in RFA of Focal Lesions in the Liver (PHASE4)
- Preop US-Guided Nerve Blocks for Pain & Recovery After Ankle Arthroscopy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Placebo oral tablet preoperative administration CI brief — competitive landscape report
- Placebo oral tablet preoperative administration updates RSS · CI watch RSS
- University of Roma La Sapienza portfolio CI
Frequently asked questions about Placebo oral tablet preoperative administration
What is Placebo oral tablet preoperative administration?
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Related
- Manufacturer: University of Roma La Sapienza — full pipeline
- Therapeutic area: All drugs in Perioperative Medicine / Anesthesiology
- Indication: Drugs for Preoperative anxiety reduction
- Indication: Drugs for Preoperative stress response modulation
- Also known as: GROUP C
- Compare: Placebo oral tablet preoperative administration vs similar drugs
- Pricing: Placebo oral tablet preoperative administration cost, discount & access