{"id":"placebo-oral-tablet-preoperative-administration","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Placebo oral tablet preoperative administration","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T04:51:24.372032+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T04:51:30.745230+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Placebo oral tablet preoperative administration","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T04:51:31.531093+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108778/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T04:51:32.446751+00:00"}},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Placebo effects operate via multiple pathways: expectancy and conditioning activate endogenous opioid and dopaminergic systems, reduce anticipatory anxiety, and modulate autonomic nervous system activity. In the preoperative context, placebo administration can reduce preoperative anxiety, lower cortisol levels, and potentially improve postoperative outcomes through reduced stress-induced physiological responses. These effects are measurable and distinct from inert administration, though the magnitude varies by individual and clinical context.","oneSentence":"A placebo tablet produces therapeutic effects through psychological and psychophysiological mechanisms, including expectancy-driven modulation of pain perception, anxiety, and stress responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:01:18.219Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T04:51:34.321496+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Preoperative anxiety reduction"},{"name":"Preoperative stress response modulation"}]},"trialDetails":[{"nctId":"NCT04751175","phase":"PHASE4","title":"Management of Pain in Lumbar Arthrodesis","status":"COMPLETED","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2013-07-04","conditions":"Pain, Postoperative","enrollment":128},{"nctId":"NCT07439666","phase":"NA","title":"NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Jacques E. 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