Last reviewed · How we verify
placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa
This combination product uses dextromethorphan as a cough suppressant, diphenhydramine as an antihistamine/sedating agent, phenylephrine as a nasal decongestant, and cocoa as a demulcent to relieve cough and cold symptoms.
This combination product uses dextromethorphan as a cough suppressant, diphenhydramine as an antihistamine/sedating agent, phenylephrine as a nasal decongestant, and cocoa as a demulcent to relieve cough and cold symptoms. Used for Cough suppression and cold symptom relief (cough, nasal congestion, allergic symptoms).
At a glance
| Generic name | placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa |
|---|---|
| Sponsor | Montefiore Medical Center |
| Drug class | Cough and cold combination product |
| Modality | Small molecule |
| Therapeutic area | Respiratory/Cold and Cough |
| Phase | FDA-approved |
Mechanism of action
Dextromethorphan acts on the cough center in the medulla to suppress cough reflex. Diphenhydramine blocks H1 histamine receptors, reducing allergic symptoms and providing sedation. Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction to relieve nasal congestion. Cocoa provides soothing demulcent properties to the throat.
Approved indications
- Cough suppression and cold symptom relief (cough, nasal congestion, allergic symptoms)
Common side effects
- Drowsiness/sedation
- Dizziness
- Dry mouth
- Nausea
- Nervousness/excitability
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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