{"id":"placebo-dextromethorphan-diphenhydramine-phenylephrine-cocoa","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness/sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Nervousness/excitability"}]},"_chembl":{"chemblId":"CHEMBL52440","moleculeType":"Small molecule","molecularWeight":"271.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dextromethorphan acts on the cough center in the medulla to suppress cough reflex. Diphenhydramine blocks H1 histamine receptors, reducing allergic symptoms and providing sedation. Phenylephrine is an alpha-1 adrenergic agonist that causes vasoconstriction to relieve nasal congestion. Cocoa provides soothing demulcent properties to the throat.","oneSentence":"This combination product uses dextromethorphan as a cough suppressant, diphenhydramine as an antihistamine/sedating agent, phenylephrine as a nasal decongestant, and cocoa as a demulcent to relieve cough and cold symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:00:41.729Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cough suppression and cold symptom relief (cough, nasal congestion, allergic symptoms)"}]},"trialDetails":[{"nctId":"NCT02062710","phase":"PHASE4","title":"Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2014-01","conditions":"Cough Reflex Sensitivity","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa","genericName":"placebo; dextromethorphan; diphenhydramine/phenylephrine/cocoa","companyName":"Montefiore Medical Center","companyId":"montefiore-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product uses dextromethorphan as a cough suppressant, diphenhydramine as an antihistamine/sedating agent, phenylephrine as a nasal decongestant, and cocoa as a demulcent to relieve cough and cold symptoms. Used for Cough suppression and cold symptom relief (cough, nasal congestion, allergic symptoms).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}