What is Arelix used for?

Arelix is indicated for Edema, Hypertensive disorder.

What development phase is Arelix in?

Arelix is FDA-approved (marketed).

What is the generic name of Arelix?

PIRETANIDE is the generic (nonproprietary) name of Arelix.

Last reviewed 2026-04-20 · How we verify

Arelix (PIRETANIDE)

FDA-approved active Small molecule Quality 26/100

Piretanide (Arelix) is a marketed diuretic used primarily for the treatment of edema, competing in a class dominated by long-standing drugs such as furosemide, bumetanide, and torsemide. Its key strength lies in its mechanism of action, which effectively blocks the sodium-potassium-chloride cotransporter in the kidneys, potentially offering a more targeted approach to fluid management. The primary risk is the upcoming key composition patent expiry in 2028, which could lead to increased competition from generics.

At a glance

Generic name	PIRETANIDE
Drug class	piretanide
Target	Solute carrier family 12 member 1
Modality	Small molecule
Therapeutic area	Cardiovascular
Phase	FDA-approved

Approved indications

Edema
Hypertensive disorder

Common side effects

No common side effects on file.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Arelix CI brief — competitive landscape report
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