{"id":"piretanide","rwe":[],"tags":[{"label":"piretanide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Solute carrier family 12 member 1","category":"target"},{"label":"SLC12A1","category":"gene"},{"label":"SLC12A2","category":"gene"},{"label":"C03CA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Edema","category":"indication"},{"label":"Hypertensive disorder","category":"indication"},{"label":"Diuretics","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"},{"label":"Natriuretic Agents","category":"pharmacology"},{"label":"Sodium Potassium Chloride Symporter Inhibitors","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":72.811,"date":"","count":18,"signal":"Blood urea increased","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=73)"},{"llr":71.457,"date":"","count":17,"signal":"Stevens-Johnson syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 17 times (LLR=71)"}],"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=PIRETANIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:58:18.478385+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T01:58:37.054167+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:58:24.823365+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PIRETANIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:58:25.155005+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL349803/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:58:25.929380+00:00"}},"allNames":"arelix","offLabel":[],"synonyms":["piretanide","arelix","diumax","eurelix"],"timeline":[{"date":"1980-01-01","type":"positive","source":"DrugCentral","milestone":"YEAR INTRODUCED approval"}],"aiSummary":"Arelix is a small molecule medication. It is also known by other names, including Piretanida, Piretanide, and Piretanide.","approvals":[{"date":"1980-01-01","orphan":false,"company":"","regulator":"YEAR INTRODUCED"}],"brandName":"Arelix","ecosystem":[{"indication":"Edema","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"bumetanide","slug":"bumetanide","company":""},{"name":"chlorothiazide","slug":"chlorothiazide","company":"Oak Pharms Akorn"}],"globalPrevalence":200000},{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"target":"Solute carrier family 12 member 1","targets":[{"gene":"SLC12A1","source":"DrugCentral","target":"Solute carrier family 12 member 1","protein":"Solute carrier family 12 member 1"},{"gene":"SLC12A2","source":"DrugCentral","target":"Solute carrier family 12 member 2","protein":"Solute carrier family 12 member 2"}],"modality":"Small Molecule","drugClass":"piretanide","explanation":"","oneSentence":"","technicalDetail":"Piretanide acts as a competitive inhibitor of the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, reducing sodium reabsorption and increasing urine production."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2201","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PIRETANIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:21:13.570421","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T01:58:37.054269+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"furosemide","drugSlug":"furosemide","fdaApproval":"1966-07-01","patentExpiry":"Apr 3, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"bumetanide","drugSlug":"bumetanide","fdaApproval":"1983-02-28","patentExpiry":"Dec 4, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"torsemide","drugSlug":"torsemide","fdaApproval":"1993-08-23","patentExpiry":"Oct 6, 2033","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"piretanide","indications":{"approved":[{"name":"Edema","source":"DrugCentral","snomedId":267038008,"regulator":"FDA","usPrevalence":null,"globalPrevalence":200000,"prevalenceMethod":"curated","prevalenceSource":"Int Arch Allergy Immunol, 2025 (PMID:39827848)"},{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"furosemide","brandName":"furosemide","genericName":"furosemide","approvalYear":"1966","relationship":"same-class"},{"drugId":"bumetanide","brandName":"bumetanide","genericName":"bumetanide","approvalYear":"1983","relationship":"same-class"},{"drugId":"torsemide","brandName":"torsemide","genericName":"torsemide","approvalYear":"1993","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"23252","NDDF":"004024","UNII":"DQ6KK6GV93","CHEBI":"CHEBI:32015","INN_ID":"3741","RXNORM":"151370","UMLSCUI":"C0071132","chemblId":"CHEMBL349803","ChEMBL_ID":"CHEMBL349803","KEGG_DRUG":"D01634","DRUGBANK_ID":"DB02925","PUBCHEM_CID":"4849","SNOMEDCT_US":"318031002","IUPHAR_LIGAND_ID":"4742","MESH_SUPPLEMENTAL_RECORD_UI":"C015451"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.3 hours","clearance":"3.1 mL/min/kg","bioavailability":"92%","fractionUnbound":"0.058%","volumeOfDistribution":"0.17 L/kg"},"publicationCount":318,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C03CA03","allCodes":["C03CA03"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"OTHER","regulator":"YEAR INTRODUCED","status":"approved","approval_date":"1980-01-01T00:00:00.000Z","mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T01:58:37.054269+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}