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PIEB: Patient Intermittent Epidural Boluses
PIEB delivers intermittent boluses of local anesthetic directly into the epidural space to provide on-demand pain relief during labor and postoperative recovery.
PIEB delivers intermittent boluses of local anesthetic directly into the epidural space to provide on-demand pain relief during labor and postoperative recovery. Used for Labor pain management, Postoperative pain management.
At a glance
| Generic name | PIEB: Patient Intermittent Epidural Boluses |
|---|---|
| Sponsor | Hospital del Rio Hortega |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Patient-controlled epidural bolus (PIEB) is an infusion technique that allows patients to self-administer periodic doses of epidural anesthetic (typically local anesthetic ± opioid) through a programmable pump, rather than receiving continuous infusion. This approach reduces total drug consumption, improves pain control, and enhances patient satisfaction by enabling individualized dosing based on pain perception.
Approved indications
- Labor pain management
- Postoperative pain management
Common side effects
- Hypotension
- Urinary retention
- Pruritus
- Nausea
- Motor blockade
Key clinical trials
- PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose (NA)
- Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia (PHASE2, PHASE3)
- Programmed Intermittent Bolus Versus Continuous Infusion for Epidural Analgesia in Abdominal Surgery (NA)
- Comparative Study of the Combination of Different Modes of Administration of Local Anesthetics in Labor Analgesia
- Comparison of PIEB vs CEI for Labor Analgesia (PHASE4)
- Epidural Analgesia During Labour (PHASE3)
- Combined Implementation of Dural Puncture Epidural and Programmed Intermittent Epidural Bolus for Labor Analgesia (NA)
- PIEB vs PCEA With Epidural or CSE Technique. A Randomized Double Blind Clinical Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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