{"id":"pieb-patient-intermittent-epidural-boluses","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Motor blockade"}]},"_chembl":{"chemblId":"CHEMBL284838","moleculeType":"Small molecule","molecularWeight":"399.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Patient-controlled epidural bolus (PIEB) is an infusion technique that allows patients to self-administer periodic doses of epidural anesthetic (typically local anesthetic ± opioid) through a programmable pump, rather than receiving continuous infusion. This approach reduces total drug consumption, improves pain control, and enhances patient satisfaction by enabling individualized dosing based on pain perception.","oneSentence":"PIEB delivers intermittent boluses of local anesthetic directly into the epidural space to provide on-demand pain relief during labor and postoperative recovery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:26:08.514Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Labor pain management"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT05534945","phase":"NA","title":"PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose","status":"RECRUITING","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2022-12-01","conditions":"Acute Post Operative Pain, Laparotomy, Epidural Analgesia","enrollment":60},{"nctId":"NCT05781854","phase":"PHASE2, PHASE3","title":"Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia","status":"RECRUITING","sponsor":"Assiut University","startDate":"2023-05-29","conditions":"Labor Pain","enrollment":60},{"nctId":"NCT04254523","phase":"NA","title":"Programmed Intermittent Bolus Versus Continuous Infusion for Epidural Analgesia in Abdominal Surgery","status":"COMPLETED","sponsor":"CHU de Quebec-Universite Laval","startDate":"2019-11-14","conditions":"Analgesia, Epidural, Pain, Postoperative","enrollment":88},{"nctId":"NCT03839056","phase":"","title":"Comparative Study of the Combination of Different Modes of Administration of Local Anesthetics in Labor Analgesia","status":"COMPLETED","sponsor":"Marian Daras","startDate":"2015-08-02","conditions":"Labor Epidural Analgesia","enrollment":151},{"nctId":"NCT02949271","phase":"PHASE4","title":"Comparison of PIEB vs CEI for Labor Analgesia","status":"COMPLETED","sponsor":"Duke University","startDate":"2016-11-08","conditions":"Labor Pain","enrollment":179},{"nctId":"NCT03133091","phase":"PHASE3","title":"Epidural Analgesia During Labour","status":"COMPLETED","sponsor":"Hospital del Rio Hortega","startDate":"2015-09","conditions":"Anesthesia, Obstetrical, Analgesia, Epidural","enrollment":200},{"nctId":"NCT03366935","phase":"NA","title":"Combined Implementation of Dural Puncture Epidural and Programmed Intermittent Epidural Bolus for Labor Analgesia","status":"COMPLETED","sponsor":"Shanghai First Maternity and Infant Hospital","startDate":"2017-10-10","conditions":"Labor Pain, Labor Analgesia","enrollment":120},{"nctId":"NCT02768272","phase":"PHASE4","title":"PIEB vs PCEA With Epidural or CSE Technique. A Randomized Double Blind Clinical Trial","status":"COMPLETED","sponsor":"Hospital Universitario La Paz","startDate":"2016-03-01","conditions":"Labor Epidural Analgesia","enrollment":240},{"nctId":"NCT02758405","phase":"NA","title":"Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor 2","status":"COMPLETED","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2016-05","conditions":"Labor Pain","enrollment":40},{"nctId":"NCT02550262","phase":"NA","title":"Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor","status":"COMPLETED","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2015-09","conditions":"Labor Pain","enrollment":40},{"nctId":"NCT00417027","phase":"NA","title":"Programmed Intermittent Epidural Bolus Time Interval and Injection Volume","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2006-08","conditions":"Labor Pain","enrollment":190}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"PIEB: Patient Intermittent Epidural Boluses","genericName":"PIEB: Patient Intermittent Epidural Boluses","companyName":"Hospital del Rio Hortega","companyId":"hospital-del-rio-hortega","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PIEB delivers intermittent boluses of local anesthetic directly into the epidural space to provide on-demand pain relief during labor and postoperative recovery. Used for Labor pain management, Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}