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Pico-Salax and Sodium phosphate enema
Pico-Salax is an osmotic laxative that draws water into the bowel to promote evacuation, while sodium phosphate enema works locally to stimulate bowel movements and cleanse the colon.
Pico-Salax is an osmotic laxative that draws water into the bowel to promote evacuation, while sodium phosphate enema works locally to stimulate bowel movements and cleanse the colon. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to barium enema or other colorectal procedures.
At a glance
| Generic name | Pico-Salax and Sodium phosphate enema |
|---|---|
| Also known as | Sodium picosulfate |
| Sponsor | Queen's University |
| Drug class | Osmotic laxative / bowel cleanser |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Pico-Salax contains picosulfate sodium and magnesium oxide, which act as osmotic agents to increase stool water content and promote bowel evacuation. Sodium phosphate enema works through osmotic and local irritant effects on the rectal mucosa to stimulate defecation. Together, these agents are used for bowel cleansing prior to diagnostic or surgical procedures.
Approved indications
- Bowel cleansing prior to colonoscopy
- Bowel cleansing prior to barium enema or other colorectal procedures
Common side effects
- Abdominal cramping
- Nausea
- Diarrhea
- Vomiting
- Electrolyte imbalance
Key clinical trials
- TES RCT Fleet Enema vs Oral Mechanical Bowel Prep (PHASE4)
- Comparing Bowel Preparation Regimens for Flexible Sigmoidoscopy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pico-Salax and Sodium phosphate enema CI brief — competitive landscape report
- Pico-Salax and Sodium phosphate enema updates RSS · CI watch RSS
- Queen's University portfolio CI