{"id":"pico-salax-and-sodium-phosphate-enema","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Electrolyte imbalance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pico-Salax contains picosulfate sodium and magnesium oxide, which act as osmotic agents to increase stool water content and promote bowel evacuation. Sodium phosphate enema works through osmotic and local irritant effects on the rectal mucosa to stimulate defecation. Together, these agents are used for bowel cleansing prior to diagnostic or surgical procedures.","oneSentence":"Pico-Salax is an osmotic laxative that draws water into the bowel to promote evacuation, while sodium phosphate enema works locally to stimulate bowel movements and cleanse the colon.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:36:00.849Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy"},{"name":"Bowel cleansing prior to barium enema or other colorectal procedures"}]},"trialDetails":[{"nctId":"NCT05148494","phase":"PHASE4","title":"TES RCT Fleet Enema vs Oral Mechanical Bowel Prep","status":"RECRUITING","sponsor":"Nova Scotia Health Authority","startDate":"2022-03-16","conditions":"Colorectal Neoplasms, Surgery","enrollment":66},{"nctId":"NCT01554111","phase":"PHASE4","title":"Comparing Bowel Preparation Regimens for Flexible Sigmoidoscopy","status":"COMPLETED","sponsor":"Queen's University","startDate":"2012-03","conditions":"Cathartic Colon","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sodium picosulfate"],"phase":"marketed","status":"active","brandName":"Pico-Salax and Sodium phosphate enema","genericName":"Pico-Salax and Sodium phosphate enema","companyName":"Queen's University","companyId":"queen-s-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pico-Salax is an osmotic laxative that draws water into the bowel to promote evacuation, while sodium phosphate enema works locally to stimulate bowel movements and cleanse the colon. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to barium enema or other colorectal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}