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PHMB 0.02%
PHMB (polyhexamethylene biguanide) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes.
PHMB (polyhexamethylene biguanide) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes. Used for Ophthalmic antimicrobial use (contact lens disinfection, eye care), Wound irrigation and antimicrobial treatment.
At a glance
| Generic name | PHMB 0.02% |
|---|---|
| Also known as | Polihexanide 0.2 mg/ml |
| Sponsor | SIFI SpA |
| Drug class | Antimicrobial agent |
| Target | Bacterial and fungal cell membranes |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology / Antimicrobial |
| Phase | Phase 3 |
Mechanism of action
PHMB works by binding to and destabilizing the cell membranes of microorganisms, leading to leakage of cellular contents and cell death. It has activity against a wide range of gram-positive and gram-negative bacteria, as well as fungi and some viruses. At the 0.02% concentration, it is used topically for antimicrobial purposes, particularly in ophthalmic and wound care applications.
Approved indications
- Ophthalmic antimicrobial use (contact lens disinfection, eye care)
- Wound irrigation and antimicrobial treatment
Common side effects
- Ocular irritation
- Conjunctival hyperemia
- Mild discomfort on instillation
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |