{"id":"phmb-0-02","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Mild discomfort on instillation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PHMB works by binding to and destabilizing the cell membranes of microorganisms, leading to leakage of cellular contents and cell death. It has activity against a wide range of gram-positive and gram-negative bacteria, as well as fungi and some viruses. At the 0.02% concentration, it is used topically for antimicrobial purposes, particularly in ophthalmic and wound care applications.","oneSentence":"PHMB (polyhexamethylene biguanide) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:38.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ophthalmic antimicrobial use (contact lens disinfection, eye care)"},{"name":"Wound irrigation and antimicrobial treatment"}]},"trialDetails":[{"nctId":"NCT03274895","phase":"PHASE3","title":"Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis","status":"COMPLETED","sponsor":"SIFI SpA","startDate":"2017-08-13","conditions":"Acanthamoeba Keratitis","enrollment":135}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Polihexanide 0.2 mg/ml"],"phase":"phase_3","status":"active","brandName":"PHMB 0.02%","genericName":"PHMB 0.02%","companyName":"SIFI SpA","companyId":"sifi-spa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PHMB (polyhexamethylene biguanide) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes. Used for Ophthalmic antimicrobial use (contact lens disinfection, eye care), Wound irrigation and antimicrobial treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}