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phenytoin and probenecid
Phenytoin is an anticonvulsant that stabilizes neuronal membranes and reduces seizure activity, while probenecid is a uricosuric agent that increases uric acid excretion and can inhibit renal tubular secretion of certain drugs.
Phenytoin is an anticonvulsant that stabilizes neuronal membranes and reduces seizure activity, while probenecid is a uricosuric agent that increases uric acid excretion and can inhibit renal tubular secretion of certain drugs. Used for Seizure disorders (phenytoin component), Gout prophylaxis (probenecid component).
At a glance
| Generic name | phenytoin and probenecid |
|---|---|
| Sponsor | Jim McAuley |
| Drug class | Anticonvulsant and uricosuric agent combination |
| Target | Voltage-gated sodium channels (phenytoin); organic acid transporter (probenecid) |
| Modality | Small molecule |
| Therapeutic area | Neurology and Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Phenytoin works by blocking voltage-gated sodium channels and modulating calcium influx, thereby reducing neuronal excitability and preventing seizure propagation. Probenecid inhibits the renal tubular reabsorption of uric acid, promoting its urinary excretion, and also competitively inhibits the secretion of certain organic acids and drugs. When combined, probenecid can increase phenytoin plasma levels by inhibiting its renal clearance.
Approved indications
- Seizure disorders (phenytoin component)
- Gout prophylaxis (probenecid component)
Common side effects
- Gingival hyperplasia
- Ataxia
- Nystagmus
- Nausea
- Rash
- Nephrolithiasis (probenecid-related)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- phenytoin and probenecid CI brief — competitive landscape report
- phenytoin and probenecid updates RSS · CI watch RSS
- Jim McAuley portfolio CI