{"id":"phenytoin-and-probenecid","safety":{"commonSideEffects":[{"rate":null,"effect":"Gingival hyperplasia"},{"rate":null,"effect":"Ataxia"},{"rate":null,"effect":"Nystagmus"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Nephrolithiasis (probenecid-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phenytoin works by blocking voltage-gated sodium channels and modulating calcium influx, thereby reducing neuronal excitability and preventing seizure propagation. Probenecid inhibits the renal tubular reabsorption of uric acid, promoting its urinary excretion, and also competitively inhibits the secretion of certain organic acids and drugs. When combined, probenecid can increase phenytoin plasma levels by inhibiting its renal clearance.","oneSentence":"Phenytoin is an anticonvulsant that stabilizes neuronal membranes and reduces seizure activity, while probenecid is a uricosuric agent that increases uric acid excretion and can inhibit renal tubular secretion of certain drugs.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:35:57.673Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure disorders (phenytoin component)"},{"name":"Gout prophylaxis (probenecid component)"}]},"trialDetails":[{"nctId":"NCT00610532","phase":"PHASE4","title":"Evaluating the Transporter Protein Inhibitor Probenecid In Patients With Epilepsy","status":"TERMINATED","sponsor":"Jim McAuley","startDate":"2006-03","conditions":"Epilepsy","enrollment":8}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"phenytoin and probenecid","genericName":"phenytoin and probenecid","companyName":"Jim McAuley","companyId":"jim-mcauley","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phenytoin is an anticonvulsant that stabilizes neuronal membranes and reduces seizure activity, while probenecid is a uricosuric agent that increases uric acid excretion and can inhibit renal tubular secretion of certain drugs. Used for Seizure disorders (phenytoin component), Gout prophylaxis (probenecid component).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}