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Pharmacological cervical ripening
Pharmacological cervical ripening is a Prostaglandin analog or cervical ripening agent Small molecule drug developed by University Hospital, Tours. It is currently in Phase 3 development for Cervical ripening prior to labor induction in term or near-term pregnancy, Preparation for vaginal delivery when cervical conditions are unfavorable.
Pharmacological cervical ripening uses medications to soften and dilate the cervix in preparation for labor or delivery.
Pharmacological cervical ripening uses medications to soften and dilate the cervix in preparation for labor or delivery. Used for Cervical ripening prior to labor induction in term or near-term pregnancy, Preparation for vaginal delivery when cervical conditions are unfavorable.
At a glance
| Generic name | Pharmacological cervical ripening |
|---|---|
| Sponsor | University Hospital, Tours |
| Drug class | Prostaglandin analog or cervical ripening agent |
| Target | Prostaglandin receptors (EP1, EP2, EP3, FP receptors) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics and Gynecology |
| Phase | Phase 3 |
Mechanism of action
This approach typically employs prostaglandin analogs (such as misoprostol or dinoprostone) or other pharmacological agents that promote cervical effacement and dilation by increasing uterine contractions and cervical compliance. The medications work by stimulating prostaglandin receptors on cervical tissue and myometrium, facilitating the physiological changes necessary for vaginal delivery when labor induction is clinically indicated.
Approved indications
- Cervical ripening prior to labor induction in term or near-term pregnancy
- Preparation for vaginal delivery when cervical conditions are unfavorable
Common side effects
- Uterine hyperstimulation
- Vaginal bleeding or spotting
- Gastrointestinal effects (nausea, diarrhea)
- Fever
- Maternal tachycardia
Key clinical trials
- Induction of Labor by Cervical Ripening and Transcutaneous Electrical Nerve Stimulation (TENS) (NA)
- Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies (PHASE3)
- Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial (NA)
- Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction (PHASE3)
- Significance of Misoprostol-induced Cervical Ripening Prior to Hysteroscopy (NA)
- Comparison Between Propess and Cook Double-balloon Catheter for Cervical Priming (PHASE4)
- Balloon to Induce Labor in Generous Women. (PHASE3)
- Early Amniotomy Versus Delayed Amniotomy Following Foley Catheter Ripening in Nulliparous Labor Induction (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pharmacological cervical ripening CI brief — competitive landscape report
- Pharmacological cervical ripening updates RSS · CI watch RSS
- University Hospital, Tours portfolio CI
Frequently asked questions about Pharmacological cervical ripening
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Related
- Drug class: All Prostaglandin analog or cervical ripening agent drugs
- Target: All drugs targeting Prostaglandin receptors (EP1, EP2, EP3, FP receptors)
- Manufacturer: University Hospital, Tours — full pipeline
- Therapeutic area: All drugs in Obstetrics and Gynecology
- Indication: Drugs for Cervical ripening prior to labor induction in term or near-term pregnancy
- Indication: Drugs for Preparation for vaginal delivery when cervical conditions are unfavorable
- Compare: Pharmacological cervical ripening vs similar drugs
- Pricing: Pharmacological cervical ripening cost, discount & access