{"id":"pharmacological-cervical-ripening","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Vaginal bleeding or spotting"},{"rate":null,"effect":"Gastrointestinal effects (nausea, diarrhea)"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Maternal tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This approach typically employs prostaglandin analogs (such as misoprostol or dinoprostone) or other pharmacological agents that promote cervical effacement and dilation by increasing uterine contractions and cervical compliance. The medications work by stimulating prostaglandin receptors on cervical tissue and myometrium, facilitating the physiological changes necessary for vaginal delivery when labor induction is clinically indicated.","oneSentence":"Pharmacological cervical ripening uses medications to soften and dilate the cervix in preparation for labor or delivery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:35.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical ripening prior to labor induction in term or near-term pregnancy"},{"name":"Preparation for vaginal delivery when cervical conditions are unfavorable"}]},"trialDetails":[{"nctId":"NCT07494539","phase":"NA","title":"Induction of Labor by Cervical Ripening and Transcutaneous Electrical Nerve Stimulation (TENS)","status":"NOT_YET_RECRUITING","sponsor":"HOT Noémie","startDate":"2026-04-01","conditions":"Labor Pain, Induction of Labor","enrollment":132},{"nctId":"NCT02907060","phase":"PHASE3","title":"Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2017-01-27","conditions":"Prolonged Pregnancy","enrollment":1224},{"nctId":"NCT07121634","phase":"NA","title":"Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Raid M. Al-Ani","startDate":"2024-01-01","conditions":"Cervical Ripening","enrollment":80},{"nctId":"NCT05774236","phase":"PHASE3","title":"Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction","status":"COMPLETED","sponsor":"Hospital Universitario 12 de Octubre","startDate":"2023-03-27","conditions":"Fetal Growth Retardation","enrollment":172},{"nctId":"NCT06726278","phase":"NA","title":"Significance of Misoprostol-induced Cervical Ripening Prior to Hysteroscopy","status":"COMPLETED","sponsor":"Hayat Abad Medical Complex, Peshawar","startDate":"2022-08-01","conditions":"Hysteroscopy, Cervical Ripening","enrollment":539},{"nctId":"NCT06438081","phase":"PHASE4","title":"Comparison Between Propess and Cook Double-balloon Catheter for Cervical Priming","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2024-06-01","conditions":"Delivery Problem","enrollment":28},{"nctId":"NCT03435458","phase":"PHASE3","title":"Balloon to Induce Labor in Generous Women.","status":"TERMINATED","sponsor":"University Hospital, Toulouse","startDate":"2020-06-26","conditions":"Maternal Obesity","enrollment":429},{"nctId":"NCT03039036","phase":"NA","title":"Early Amniotomy Versus Delayed Amniotomy Following Foley Catheter Ripening in Nulliparous Labor Induction","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2017-09-12","conditions":"Labor Induction","enrollment":69},{"nctId":"NCT05568745","phase":"PHASE4","title":"Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2023-01-18","conditions":"Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes","enrollment":520},{"nctId":"NCT03928600","phase":"NA","title":"Labor Induction With a Combined Method (Pharmacologic and Mechanical): Randomized Controlled Trial","status":"COMPLETED","sponsor":"Centro Hospitalar De São João, E.P.E.","startDate":"2018-02-01","conditions":"Labor, Induced, Cervical Ripening","enrollment":140},{"nctId":"NCT04496908","phase":"EARLY_PHASE1","title":"Early Versus Delayed Artificial Rupture of Membranes (AROM Trial)","status":"COMPLETED","sponsor":"Christiana Care Health Services","startDate":"2020-09-16","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":160},{"nctId":"NCT03001661","phase":"PHASE3","title":"An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt","status":"COMPLETED","sponsor":"Birmingham Women's NHS Foundation Trust","startDate":"2017-12-19","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":674},{"nctId":"NCT04152317","phase":"PHASE3","title":"Dose Comparison of Misoprostol for Cervix Ripening Before Operative Hysteroscopy.","status":"COMPLETED","sponsor":"Professor Fernando Figueira Integral Medicine Institute","startDate":"2019-11-07","conditions":"Cervix; Open","enrollment":80},{"nctId":"NCT02393144","phase":"NA","title":"Analysis of Contemporary Labor Patterns Measured Via Transperineal Ultrasonography","status":"UNKNOWN","sponsor":"Ankara University","startDate":"2015-02","conditions":"Pregnancy, Obstetric Labor","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pharmacological cervical ripening","genericName":"Pharmacological cervical ripening","companyName":"University Hospital, Tours","companyId":"university-hospital-tours","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pharmacological cervical ripening uses medications to soften and dilate the cervix in preparation for labor or delivery. Used for Cervical ripening prior to labor induction in term or near-term pregnancy, Preparation for vaginal delivery when cervical conditions are unfavorable.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}