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pethidine and haloperidol injection
Pethidine acts as an opioid analgesic while haloperidol acts as a dopamine antagonist antipsychotic, together providing analgesia and sedation with antipsychotic effects.
Pethidine acts as an opioid analgesic while haloperidol acts as a dopamine antagonist antipsychotic, together providing analgesia and sedation with antipsychotic effects. Used for Acute pain management with sedation and anxiolysis in hospital settings, Pain management in patients requiring antipsychotic or antiemetic effects.
At a glance
| Generic name | pethidine and haloperidol injection |
|---|---|
| Also known as | meperidine and haloperidol injection |
| Sponsor | Hospital General Universitario Gregorio Marañon |
| Drug class | Opioid analgesic + typical antipsychotic combination |
| Target | Mu opioid receptor (pethidine); dopamine D2 receptor (haloperidol) |
| Modality | Small molecule |
| Therapeutic area | Pain management / Psychiatry |
| Phase | FDA-approved |
Mechanism of action
Pethidine is a synthetic opioid that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation. Haloperidol is a typical antipsychotic that blocks dopamine D2 receptors, providing antipsychotic and antiemetic effects. This combination is used for acute pain management with sedation and to reduce agitation or psychotic symptoms.
Approved indications
- Acute pain management with sedation and anxiolysis in hospital settings
- Pain management in patients requiring antipsychotic or antiemetic effects
Common side effects
- Respiratory depression
- Hypotension
- Sedation
- Extrapyramidal symptoms
- Nausea
- Dizziness
Key clinical trials
- Birth Ball Versus Meperidine and Haloperidol Injection for Pain Relief During First Stage of Labour (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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