{"id":"pethidine-and-haloperidol-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Extrapyramidal symptoms"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pethidine is a synthetic opioid that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation. Haloperidol is a typical antipsychotic that blocks dopamine D2 receptors, providing antipsychotic and antiemetic effects. This combination is used for acute pain management with sedation and to reduce agitation or psychotic symptoms.","oneSentence":"Pethidine acts as an opioid analgesic while haloperidol acts as a dopamine antagonist antipsychotic, together providing analgesia and sedation with antipsychotic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:28.560Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management with sedation and anxiolysis in hospital settings"},{"name":"Pain management in patients requiring antipsychotic or antiemetic effects"}]},"trialDetails":[{"nctId":"NCT02493192","phase":"PHASE4","title":"Birth Ball Versus Meperidine and Haloperidol Injection for Pain Relief During First Stage of Labour","status":"UNKNOWN","sponsor":"Hospital General Universitario Gregorio Marañon","startDate":"2015-07","conditions":"Parturition, Humanizing Deliver, Labor Pain","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["meperidine and haloperidol injection"],"phase":"marketed","status":"active","brandName":"pethidine and haloperidol injection","genericName":"pethidine and haloperidol injection","companyName":"Hospital General Universitario Gregorio Marañon","companyId":"hospital-general-universitario-gregorio-mara-on","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pethidine acts as an opioid analgesic while haloperidol acts as a dopamine antagonist antipsychotic, together providing analgesia and sedation with antipsychotic effects. Used for Acute pain management with sedation and anxiolysis in hospital settings, Pain management in patients requiring antipsychotic or antiemetic effects.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}