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Permethrin 10 % Creme
Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasitic arthropods, causing paralysis and death.
Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasitic arthropods, causing paralysis and death. Used for Scabies (Sarcoptes scabiei infestation), Head lice (Pediculus humanus capitis), Body lice (Pediculus humanus humanus).
At a glance
| Generic name | Permethrin 10 % Creme |
|---|---|
| Sponsor | Infectopharm Arzneimittel GmbH |
| Drug class | Pyrethroid insecticide |
| Target | Voltage-gated sodium channels (arthropod nervous system) |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Parasitology |
| Phase | Phase 3 |
Mechanism of action
Permethrin acts as a neurotoxin by binding to voltage-gated sodium channels in nerve cell membranes of insects and mites, prolonging their opening and causing repetitive neuronal firing. This leads to paralysis and death of the parasite. The drug is selective for arthropod nervous systems due to differences in sodium channel structure and metabolism compared to mammals.
Approved indications
- Scabies (Sarcoptes scabiei infestation)
- Head lice (Pediculus humanus capitis)
- Body lice (Pediculus humanus humanus)
- Pubic lice (Phthirus pubis)
Common side effects
- Pruritus
- Erythema
- Burning sensation
- Skin irritation
- Transient paresthesia
Key clinical trials
- A Study to Evaluate the Efficacy and Safety of a Leave-in Spray in Subjects With Head Lice Infestation (PHASE4)
- Therapy for Scabies With Two Differently Concentrated Permethrin Creams (PHASE3)
- Escalated Therapy of Scabies With INFECTOSCAB 5% (Permethrin) (PHASE3)
- Cocamide DEA vs Permethrin for Head Lice (PHASE3)
- Efficacy and Safety of Licefreee Spray Against Nix 1% Permethrin (NA)
- Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice (PHASE3)
- Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice (PHASE3)
- Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Permethrin 10 % Creme CI brief — competitive landscape report
- Permethrin 10 % Creme updates RSS · CI watch RSS
- Infectopharm Arzneimittel GmbH portfolio CI