{"id":"permethrin-10-creme","safety":{"commonSideEffects":[{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Transient paresthesia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Permethrin acts as a neurotoxin by binding to voltage-gated sodium channels in nerve cell membranes of insects and mites, prolonging their opening and causing repetitive neuronal firing. This leads to paralysis and death of the parasite. The drug is selective for arthropod nervous systems due to differences in sodium channel structure and metabolism compared to mammals.","oneSentence":"Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasitic arthropods, causing paralysis and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:34.570Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Scabies (Sarcoptes scabiei infestation)"},{"name":"Head lice (Pediculus humanus capitis)"},{"name":"Body lice (Pediculus humanus humanus)"},{"name":"Pubic lice (Phthirus pubis)"}]},"trialDetails":[{"nctId":"NCT05565820","phase":"PHASE4","title":"A Study to Evaluate the Efficacy and Safety of a Leave-in Spray in Subjects With Head Lice Infestation","status":"COMPLETED","sponsor":"Alliance Pharmaceuticals","startDate":"2022-12-15","conditions":"Pediculosis Capitis, Lice Infestations, Head Lice","enrollment":58},{"nctId":"NCT06380452","phase":"PHASE3","title":"Therapy for Scabies With Two Differently Concentrated Permethrin Creams","status":"NOT_YET_RECRUITING","sponsor":"Infectopharm Arzneimittel GmbH","startDate":"2024-05","conditions":"Scabies","enrollment":220},{"nctId":"NCT04814511","phase":"PHASE3","title":"Escalated Therapy of Scabies With INFECTOSCAB 5% (Permethrin)","status":"UNKNOWN","sponsor":"Infectopharm Arzneimittel GmbH","startDate":"2021-06-11","conditions":"Scabies","enrollment":183},{"nctId":"NCT02500524","phase":"PHASE3","title":"Cocamide DEA vs Permethrin for Head Lice","status":"TERMINATED","sponsor":"Medical Entomology Centre","startDate":"1998-07","conditions":"Pediculosis Capitis, Head Louse Infestation","enrollment":44},{"nctId":"NCT01514513","phase":"NA","title":"Efficacy and Safety of Licefreee Spray Against Nix 1% Permethrin","status":"COMPLETED","sponsor":"South Florida Family Health and Research Centers","startDate":"2011-08","conditions":"Pediculosis Capitis","enrollment":42},{"nctId":"NCT00927472","phase":"PHASE3","title":"Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2009-08","conditions":"Pediculosis","enrollment":254},{"nctId":"NCT00545168","phase":"PHASE3","title":"Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2007-09","conditions":"Pediculus Capitis Infestation","enrollment":480},{"nctId":"NCT00545753","phase":"PHASE3","title":"Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2007-09","conditions":"Pediculosis","enrollment":558},{"nctId":"NCT00857935","phase":"PHASE2","title":"A Safety and Efficacy Pilot Study Comparing NatrOVA Creme Rinse 1% and NIX Creme Rinse","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2007-03","conditions":"Pediculosis Capitis, Head Lice","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Permethrin 10 % Creme","genericName":"Permethrin 10 % Creme","companyName":"Infectopharm Arzneimittel GmbH","companyId":"infectopharm-arzneimittel-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasitic arthropods, causing paralysis and death. Used for Scabies (Sarcoptes scabiei infestation), Head lice (Pediculus humanus capitis), Body lice (Pediculus humanus humanus).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}