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periprostatic nerve blockade
Periprostatic nerve blockade is a local anesthetic technique that blocks nerve conduction around the prostate to reduce pain during urological procedures.
Periprostatic nerve blockade is a local anesthetic technique that blocks nerve conduction around the prostate to reduce pain during urological procedures. Used for Pain management during transrectal ultrasound-guided prostate biopsy, Anesthesia for transrectal urological procedures.
At a glance
| Generic name | periprostatic nerve blockade |
|---|---|
| Also known as | No name |
| Sponsor | Bagcilar Training and Research Hospital |
| Modality | Small molecule |
| Therapeutic area | Urology |
| Phase | FDA-approved |
Mechanism of action
This is a regional anesthesia procedure rather than a systemically administered drug. It involves injection of local anesthetic agents (typically lidocaine or bupivacaine) around the prostate gland to anesthetize the periprostatic nerves. This blocks pain signals during transrectal ultrasound-guided biopsy and other transrectal procedures without requiring general anesthesia.
Approved indications
- Pain management during transrectal ultrasound-guided prostate biopsy
- Anesthesia for transrectal urological procedures
Common side effects
- Transient rectal discomfort
- Bleeding or hematochezia
- Infection or prostatitis
- Local anesthetic toxicity (rare)
Key clinical trials
- TENS for Pain Relief During Fusion-Guided Prostate Biopsy (NA)
- AcuTENS for Pain Relief During TRUS-Guided Prostate Biopsy (NA)
- Hypnosis Mask: a New Approach to Management of Pain in Medical Imaging (NA)
- Periprostatic Nerve Block vs. Intravenous Ibuprofen for Pain Management During Transrectal Prostate Biopsy (NA)
- Self-Administered Nitrous Oxide (SANO) During Transrectal Prostate Biopsy to Reduce Patient Anxiety and Pain (PHASE4)
- Anesthesia in PROstate Biopsy Pain Obstruction Study (NA)
- Pain and Anxiety During Transrectal Prostate Biopsy (NA)
- Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |