{"id":"periprostatic-nerve-blockade","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient rectal discomfort"},{"rate":null,"effect":"Bleeding or hematochezia"},{"rate":null,"effect":"Infection or prostatitis"},{"rate":null,"effect":"Local anesthetic toxicity (rare)"}]},"_chembl":{"chemblId":"CHEMBL4297796","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a regional anesthesia procedure rather than a systemically administered drug. It involves injection of local anesthetic agents (typically lidocaine or bupivacaine) around the prostate gland to anesthetize the periprostatic nerves. This blocks pain signals during transrectal ultrasound-guided biopsy and other transrectal procedures without requiring general anesthesia.","oneSentence":"Periprostatic nerve blockade is a local anesthetic technique that blocks nerve conduction around the prostate to reduce pain during urological procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:09.070Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain management during transrectal ultrasound-guided prostate biopsy"},{"name":"Anesthesia for transrectal urological procedures"}]},"trialDetails":[{"nctId":"NCT07331246","phase":"NA","title":"TENS for Pain Relief During Fusion-Guided Prostate Biopsy","status":"COMPLETED","sponsor":"Medical University of Gdansk","startDate":"2023-12-01","conditions":"Prostate Cancer, Prostate Biopsy, Fusion Biopsy","enrollment":84},{"nctId":"NCT07292337","phase":"NA","title":"AcuTENS for Pain Relief During TRUS-Guided Prostate Biopsy","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Malaya","startDate":"2024-12-01","conditions":"Prostate Cancer, Procedural Pain Relief, TRANSRECTAL ULTRASOUND-GUIDED PROSTATE BIOPSY","enrollment":53},{"nctId":"NCT03711643","phase":"NA","title":"Hypnosis Mask: a New Approach to Management of Pain in Medical Imaging","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2019-05-07","conditions":"Prostatic Diseases","enrollment":88},{"nctId":"NCT06737939","phase":"NA","title":"Periprostatic Nerve Block vs. Intravenous Ibuprofen for Pain Management During Transrectal Prostate Biopsy","status":"COMPLETED","sponsor":"University of Gaziantep","startDate":"2023-06-01","conditions":"Pain, Acute","enrollment":128},{"nctId":"NCT05803096","phase":"PHASE4","title":"Self-Administered Nitrous Oxide (SANO) During Transrectal Prostate Biopsy to Reduce Patient Anxiety and Pain","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2021-12-12","conditions":"Prostate Disease, Malignancy, Benign Prostatic Hyperplasia","enrollment":143},{"nctId":"NCT04501055","phase":"NA","title":"Anesthesia in PROstate Biopsy Pain Obstruction Study","status":"COMPLETED","sponsor":"Shanghai East Hospital","startDate":"2020-08-13","conditions":"Prostate Cancer","enrollment":192},{"nctId":"NCT05358223","phase":"NA","title":"Pain and Anxiety During Transrectal Prostate Biopsy","status":"UNKNOWN","sponsor":"Zonguldak Bulent Ecevit University","startDate":"2022-03-14","conditions":"Prostate Biopsy","enrollment":150},{"nctId":"NCT04064047","phase":"NA","title":"Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy","status":"COMPLETED","sponsor":"Assaf-Harofeh Medical Center","startDate":"2016-12","conditions":"Pain, Prostate Cancer, Rectal/Anal","enrollment":284},{"nctId":"NCT03681522","phase":"NA","title":"A Study on the Pain Control Effect of the Anesthetic Method During Prostate Biopsy: Comparison Between Pelvic Plexus Block and Periprosthetic Nerve Block","status":"UNKNOWN","sponsor":"Gangnam Severance Hospital","startDate":"2018-09-10","conditions":"Transrectal Systematic Prostate Biopsy Related Pain","enrollment":58},{"nctId":"NCT02025361","phase":"PHASE4","title":"Impact of Local Anesthesia Type on Cancer Detection Rate in Transrectal Ultrasound Guided Prostate Biopsy","status":"COMPLETED","sponsor":"Bagcilar Training and Research Hospital","startDate":"2009-02","conditions":"Adenocarcinoma of Prostate","enrollment":422},{"nctId":"NCT02935972","phase":"PHASE2, PHASE3","title":"Combined Intravenous Diazepam, Local Periprostatic Nerve Block for Prostate Biopsy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2013-11","conditions":"Pain Relief During Prostate Biopsy","enrollment":336}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["No name"],"phase":"marketed","status":"active","brandName":"periprostatic nerve blockade","genericName":"periprostatic nerve blockade","companyName":"Bagcilar Training and Research Hospital","companyId":"bagcilar-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Periprostatic nerve blockade is a local anesthetic technique that blocks nerve conduction around the prostate to reduce pain during urological procedures. Used for Pain management during transrectal ultrasound-guided prostate biopsy, Anesthesia for transrectal urological procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}