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Perioperative magnesium sulfate
Magnesium sulfate acts as a natural calcium antagonist and NMDA receptor antagonist, reducing neuromuscular excitability and vascular smooth muscle contractility.
Magnesium sulfate acts as a natural calcium antagonist and NMDA receptor antagonist, reducing neuromuscular excitability and vascular smooth muscle contractility. Used for Perioperative seizure prophylaxis, Perioperative pain management and anesthesia adjunct, Perioperative hypertension and arrhythmia management.
At a glance
| Generic name | Perioperative magnesium sulfate |
|---|---|
| Sponsor | Instituto Mexicano del Seguro Social |
| Drug class | Electrolyte supplement / NMDA receptor antagonist |
| Target | NMDA receptor, voltage-gated calcium channels |
| Modality | Small molecule |
| Therapeutic area | Perioperative medicine / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Magnesium blocks calcium influx into cells and antagonizes N-methyl-D-aspartate (NMDA) receptors, leading to decreased neuromuscular transmission and vasodilation. In the perioperative setting, it is used to reduce seizure risk, modulate pain, and stabilize hemodynamics during and after surgery.
Approved indications
- Perioperative seizure prophylaxis
- Perioperative pain management and anesthesia adjunct
- Perioperative hypertension and arrhythmia management
Common side effects
- Flushing
- Hypotension
- Hypermagnesemia
- Muscle weakness
- Respiratory depression
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Magnesium Sulfate Infusion on Postoperative Pain in Lumbar Surgery (NA)
- Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy (PHASE1, PHASE2)
- Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery (PHASE1, PHASE2)
- Magnesium Supplementation in Simultaneous Pancreas-Kidney Transplantation
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Neoadjuvant Chemotherapy With Gemcitabine Plus Cisplatin Followed by Radical Liver Resection Versus Immediate Radical Liver Resection Alone With or Without Adjuvant Chemotherapy in Incidentally Detected Gallbladder Carcinoma After Simple Cholecystectomy or in Front of Radical Resection of BTC (PHASE3)
- Dexamethasone Versus Mg Added to Bupivacaine Used in ESPB for Perioperative Pain Control in Patients Undergoing Unilateral Nephrectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Perioperative magnesium sulfate CI brief — competitive landscape report
- Perioperative magnesium sulfate updates RSS · CI watch RSS
- Instituto Mexicano del Seguro Social portfolio CI