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Perineural Dexamethasone and bupivacaine
Perineural dexamethasone and bupivacaine combination provides local anesthesia and reduces inflammation at the nerve injection site to prolong anesthetic duration and reduce postoperative pain.
Perineural dexamethasone and bupivacaine combination provides local anesthesia and reduces inflammation at the nerve injection site to prolong anesthetic duration and reduce postoperative pain. Used for Peripheral nerve blocks for surgical anesthesia and postoperative pain management, Regional anesthesia adjuvant therapy.
At a glance
| Generic name | Perineural Dexamethasone and bupivacaine |
|---|---|
| Sponsor | Sherif Mohamed Abd el moneim Soaida, MD |
| Drug class | Local anesthetic with adjuvant corticosteroid |
| Target | Voltage-gated sodium channels (bupivacaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission. Dexamethasone, a corticosteroid, is added to the perineural injection to reduce local inflammation and potentially extend the duration of the nerve block by decreasing nerve inflammation and improving local tissue conditions.
Approved indications
- Peripheral nerve blocks for surgical anesthesia and postoperative pain management
- Regional anesthesia adjuvant therapy
Common side effects
- Transient nerve irritation
- Local tissue reaction
- Systemic toxicity from local anesthetic (rare)
- Infection at injection site
Key clinical trials
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (PHASE4)
- Proximal Versus Distal Superior Cluneal Nerve Block in Entrapment Neuropathy
- Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block (PHASE4)
- Prevention of Rebound Pain After Axillary Block (NA)
- The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery (PHASE4)
- Stellate Ganglion Blockade in Corona Virus 2019 (COVID-19) Positive Patients (PHASE1)
- Pecto-intercostal Fascial Block (PIFB) for Postop Analgesia Following Sternotomy in Cardiac Surgery Patients (PHASE4)
- Pharmacokinetic Analysis of Bupivacaine in the Presence and Absence of Perineural Dexamethasone in Axillary Blockade (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |