{"id":"perineural-dexamethasone-and-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient nerve irritation"},{"rate":null,"effect":"Local tissue reaction"},{"rate":null,"effect":"Systemic toxicity from local anesthetic (rare)"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission. Dexamethasone, a corticosteroid, is added to the perineural injection to reduce local inflammation and potentially extend the duration of the nerve block by decreasing nerve inflammation and improving local tissue conditions.","oneSentence":"Perineural dexamethasone and bupivacaine combination provides local anesthesia and reduces inflammation at the nerve injection site to prolong anesthetic duration and reduce postoperative pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:33:54.794Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Peripheral nerve blocks for surgical anesthesia and postoperative pain management"},{"name":"Regional anesthesia adjuvant therapy"}]},"trialDetails":[{"nctId":"NCT07097493","phase":"PHASE4","title":"Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-04","conditions":"Knee Arthroplasty, Total","enrollment":90},{"nctId":"NCT07372430","phase":"","title":"Proximal Versus Distal Superior Cluneal Nerve Block in Entrapment Neuropathy","status":"RECRUITING","sponsor":"Gaziosmanpasa Research and Education Hospital","startDate":"2025-12-12","conditions":"Cluneal Syndrome","enrollment":54},{"nctId":"NCT07299877","phase":"PHASE4","title":"Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block","status":"NOT_YET_RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-12-28","conditions":"Brachial Plexus Blocks","enrollment":75},{"nctId":"NCT07313553","phase":"NA","title":"Prevention of Rebound Pain After Axillary Block","status":"NOT_YET_RECRUITING","sponsor":"University Tunis El Manar","startDate":"2026-01-12","conditions":"Pain, Postoperative Care","enrollment":60},{"nctId":"NCT06806410","phase":"PHASE4","title":"The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Luke's Hospital, Pennsylvania","startDate":"2023-05-01","conditions":"Hand Surgery, Wrist Surgery, Elbow Surgery","enrollment":120},{"nctId":"NCT04445337","phase":"PHASE1","title":"Stellate Ganglion Blockade in Corona Virus 2019 (COVID-19) Positive Patients","status":"TERMINATED","sponsor":"University of Nebraska","startDate":"2020-11-15","conditions":"COVID 19, ARDS","enrollment":1},{"nctId":"NCT05676814","phase":"PHASE4","title":"Pecto-intercostal Fascial Block (PIFB) for Postop Analgesia Following Sternotomy in Cardiac Surgery Patients","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-03-24","conditions":"Analgesia, Sternotomy","enrollment":31},{"nctId":"NCT05359731","phase":"PHASE4","title":"Pharmacokinetic Analysis of Bupivacaine in the Presence and Absence of Perineural Dexamethasone in Axillary Blockade","status":"COMPLETED","sponsor":"University of Chile","startDate":"2022-06-28","conditions":"Analgesia, Acute Pain, Upper Extremity Injury","enrollment":20},{"nctId":"NCT05918796","phase":"PHASE1","title":"Comparison Between Bupivacaine and Bupivacaine- Dexamethasone QLB for Postoperative Analgesia","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-06-15","conditions":"Post Operative Pain","enrollment":60},{"nctId":"NCT04817982","phase":"PHASE2","title":"Does Perineural Dexamethasone Increase the Duration of an Ulnar Nerve Block When Controlling for Systemic Effects?","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2021-04-07","conditions":"Anesthesia, Local","enrollment":16},{"nctId":"NCT04633850","phase":"","title":"Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients","status":"COMPLETED","sponsor":"Jannie Bisgaard Stæhr","startDate":"2020-09-08","conditions":"Postoperative Pain, Lung Cancer, Video Assisted Thoracoscopic Surgery","enrollment":45},{"nctId":"NCT02506660","phase":"PHASE4","title":"Interscalene Block With Low-dose IV vs. Perineural Dexamethasone for Shoulder Arthroscopy","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2015-08","conditions":"Pain, Shoulder Arthroscopy","enrollment":128},{"nctId":"NCT02253784","phase":"NA","title":"Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Hillel Yaffe Medical Center","startDate":"2014-10","conditions":"Analgesia, Pain, Postoperative","enrollment":90},{"nctId":"NCT02426736","phase":"PHASE4","title":"Effect of Dexamethasone Dose and Route on Duration of Interscalene Block After Outpatient Shoulder Surgery","status":"COMPLETED","sponsor":"University of Manitoba","startDate":"2015-06-25","conditions":"Pain, Postoperative, Disorder of Shoulder","enrollment":280},{"nctId":"NCT03074773","phase":"PHASE1","title":"The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta","status":"COMPLETED","sponsor":"Cairo University","startDate":"2016-10-30","conditions":"Coarctation of Aorta","enrollment":50},{"nctId":"NCT02526199","phase":"PHASE4","title":"Protracted Mixture of Local Anesthetics for Major Foot and Ankle Surgery","status":"COMPLETED","sponsor":"Rasmus Wulff Hauritz","startDate":"2015-08","conditions":"Postoperative Pain","enrollment":56},{"nctId":"NCT02576782","phase":"PHASE4","title":"Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries","status":"COMPLETED","sponsor":"Sherif Mohamed Abd el moneim Soaida, MD","startDate":"2013-06","conditions":"Pain","enrollment":63},{"nctId":"NCT02248870","phase":"PHASE4","title":"Femoral Nerve Block With Bupivacaine and Adjuvant Dexamethasone in Patients With Hip Fracture","status":"TERMINATED","sponsor":"University of Aarhus","startDate":"2015-03","conditions":"Hip Fracture","enrollment":7},{"nctId":"NCT02190760","phase":"NA","title":"Comparison Between Perineural and Systemic Effect of Dexamethasone for Interscalene Brachial Plexus Block.","status":"UNKNOWN","sponsor":"Hillel Yaffe Medical Center","startDate":"2014-09","conditions":"Analgesia","enrollment":90},{"nctId":"NCT01538459","phase":"PHASE3","title":"Plasma Glucose Levels With Dexamethasone as Adjuvant to Interscalene Block","status":"WITHDRAWN","sponsor":"Lifespan","startDate":"2012-11","conditions":"Shoulder Pain, Injury of Shoulder Region, Disorder of Shoulder","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Perineural Dexamethasone and bupivacaine","genericName":"Perineural Dexamethasone and bupivacaine","companyName":"Sherif Mohamed Abd el moneim Soaida, MD","companyId":"sherif-mohamed-abd-el-moneim-soaida-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Perineural dexamethasone and bupivacaine combination provides local anesthesia and reduces inflammation at the nerve injection site to prolong anesthetic duration and reduce postoperative pain. Used for Peripheral nerve blocks for surgical anesthesia and postoperative pain management, Regional anesthesia adjuvant therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}