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perineural dexamethasone
perineural dexamethasone is a Corticosteroid Small molecule drug developed by Poznan University of Medical Sciences. It is currently FDA-approved for Prolongation of peripheral nerve blocks and regional anesthesia, Postoperative pain management. Also known as: Dexamethasone Sodium Phosphate Injection, Nerve block with local anesthetic and dexamethasone, Decoin.
Perineural dexamethasone is a corticosteroid administered adjacent to a nerve to reduce inflammation and prolong the duration of regional anesthesia.
Perineural dexamethasone is a corticosteroid administered adjacent to a nerve to reduce inflammation and prolong the duration of regional anesthesia. Used for Prolongation of peripheral nerve blocks and regional anesthesia, Postoperative pain management.
At a glance
| Generic name | perineural dexamethasone |
|---|---|
| Also known as | Dexamethasone Sodium Phosphate Injection, Nerve block with local anesthetic and dexamethasone, Decoin |
| Sponsor | Poznan University of Medical Sciences |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Dexamethasone, a potent glucocorticoid, suppresses local inflammatory responses when deposited in the perineural space around a nerve. This anti-inflammatory action reduces edema and nerve irritation, thereby extending the analgesic duration of local anesthetic blocks. The mechanism involves inhibition of phospholipase A2 and reduction of prostaglandin and cytokine production at the injection site.
Approved indications
- Prolongation of peripheral nerve blocks and regional anesthesia
- Postoperative pain management
Common side effects
- Hyperglycemia
- Local tissue irritation
- Infection risk (with repeated use)
Key clinical trials
- Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome (NA)
- The Effect of Dexamethasone Administration Route in PENG Block for Pediatric Hip Surgery (PHASE4)
- Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery (NA)
- PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults (NA)
- PENG Block Optimization: Volume and Dexamethasone Effects (PHASE4)
- Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults (NA)
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (PHASE4)
- Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- perineural dexamethasone CI brief — competitive landscape report
- perineural dexamethasone updates RSS · CI watch RSS
- Poznan University of Medical Sciences portfolio CI
Frequently asked questions about perineural dexamethasone
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Related
- Drug class: All Corticosteroid drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: Poznan University of Medical Sciences — full pipeline
- Therapeutic area: All drugs in Anesthesia / Pain Management
- Indication: Drugs for Prolongation of peripheral nerve blocks and regional anesthesia
- Indication: Drugs for Postoperative pain management
- Also known as: Dexamethasone Sodium Phosphate Injection, Nerve block with local anesthetic and dexamethasone, Decoin
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing