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Periarticular Injection (PAI)
Periarticular injection delivers therapeutic agents directly into the tissue surrounding a joint to reduce inflammation and pain during or after orthopedic surgery.
Periarticular injection delivers therapeutic agents directly into the tissue surrounding a joint to reduce inflammation and pain during or after orthopedic surgery. Used for Perioperative pain management in orthopedic surgery (e.g., total knee arthroplasty, total hip arthroplasty), Postoperative analgesia and inflammation reduction.
At a glance
| Generic name | Periarticular Injection (PAI) |
|---|---|
| Sponsor | Hospital for Special Surgery, New York |
| Modality | Small molecule |
| Therapeutic area | Orthopedic Surgery / Pain Management |
| Phase | FDA-approved |
Mechanism of action
PAI is a surgical technique rather than a discrete drug entity, involving infiltration of local anesthetics, corticosteroids, and/or other anti-inflammatory agents into the soft tissues around a joint. This localized delivery reduces postoperative pain, swelling, and opioid consumption while potentially improving functional recovery. The approach is commonly used in joint replacement and arthroscopic procedures.
Approved indications
- Postoperative pain management in total knee arthroplasty
- Postoperative pain management in total hip arthroplasty
- Pain reduction in arthroscopic joint procedures
Common side effects
- Local tissue irritation or inflammation
- Infection at injection site
- Systemic toxicity from local anesthetic (rare)
Key clinical trials
- The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties (NA)
- PENG Block vs PENG Plus Periarticular Injection vs Periarticular Injection in Older Adults (NA)
- Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery. (PHASE2, PHASE3)
- Block and Periarticular Injection Study (PHASE4)
- Acupuncture for Low-Dose Opioid for TKA Replacement (NA)
- Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI) (PHASE4)
- Does PAI Reduce Pain After TKA Among Knee Arthroplasty Patients Receiving ACB & IPACK? (PHASE4)
- Minimal Opioid Use After Total Hip Replacement (THR) (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Periarticular Injection (PAI) CI brief — competitive landscape report
- Periarticular Injection (PAI) updates RSS · CI watch RSS
- Hospital for Special Surgery, New York portfolio CI