{"id":"periarticular-injection-pai","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation or inflammation"},{"rate":null,"effect":"Infection at injection site"},{"rate":null,"effect":"Systemic toxicity from local anesthetic (rare)"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PAI is a surgical technique rather than a discrete drug entity, involving infiltration of local anesthetics, corticosteroids, and/or other anti-inflammatory agents into the soft tissues around a joint. This localized delivery reduces postoperative pain, swelling, and opioid consumption while potentially improving functional recovery. The approach is commonly used in joint replacement and arthroscopic procedures.","oneSentence":"Periarticular injection delivers therapeutic agents directly into the tissue surrounding a joint to reduce inflammation and pain during or after orthopedic surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:36:29.862Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management in total knee arthroplasty"},{"name":"Postoperative pain management in total hip arthroplasty"},{"name":"Pain reduction in arthroscopic joint procedures"}]},"trialDetails":[{"nctId":"NCT07236073","phase":"NA","title":"The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2023-07-15","conditions":"Osteoarthritis, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total","enrollment":60},{"nctId":"NCT07327892","phase":"NA","title":"PENG Block vs PENG Plus Periarticular Injection vs Periarticular Injection in Older Adults","status":"NOT_YET_RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-01","conditions":"Hip Osteoarthritis, Arthropathy of Hip","enrollment":108},{"nctId":"NCT07151417","phase":"PHASE2, PHASE3","title":"Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Walter Reed National Military Medical Center","startDate":"2025-09-01","conditions":"Knee Osteoarthritis, Musculoskeletal Disease, Surgery","enrollment":240},{"nctId":"NCT06410612","phase":"PHASE4","title":"Block and Periarticular Injection Study","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2024-03-04","conditions":"Pain, Postoperative","enrollment":160},{"nctId":"NCT04084288","phase":"NA","title":"Acupuncture for Low-Dose Opioid for TKA Replacement","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2019-08-21","conditions":"Knee Osteoarthritis, Pain, Postoperative, Acupuncture","enrollment":41},{"nctId":"NCT03094663","phase":"PHASE4","title":"Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-02-28","conditions":"Knee Arthropathy","enrollment":86},{"nctId":"NCT04749615","phase":"PHASE4","title":"Does PAI Reduce Pain After TKA Among Knee Arthroplasty Patients Receiving ACB & IPACK?","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2020-12-17","conditions":"Total Knee Athroplasty","enrollment":94},{"nctId":"NCT03090152","phase":"PHASE4","title":"Minimal Opioid Use After Total Hip Replacement (THR)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-03-08","conditions":"Osteoarthritis, Hip","enrollment":180},{"nctId":"NCT06701695","phase":"NA","title":"Efficacy of Intraoperative Periarticular Injections in Hip Fracture Hemiarthroplasty","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2020-05-11","conditions":"Femoral Neck Fractures, Hemiarthroplasty, Blood Loss Requiring Transfusion","enrollment":84},{"nctId":"NCT06630520","phase":"NA","title":"Intraoperative Periarticular Injection in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery","status":"COMPLETED","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2022-03-20","conditions":"Anterior Cruciate Ligament (ACL) Tear, Arthroscopic Anterior Cruciate Ligament Reconstruction","enrollment":288},{"nctId":"NCT03977454","phase":"PHASE2","title":"Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Yale University","startDate":"2019-11-11","conditions":"Hip Arthropathy","enrollment":192},{"nctId":"NCT04814303","phase":"NA","title":"Impact of Adductor Canal Block on Functional Recovery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-05","conditions":"Total Knee Replacement","enrollment":200},{"nctId":"NCT03653416","phase":"PHASE4","title":"Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2018-03-01","conditions":"Osteo Arthritis Knee","enrollment":99},{"nctId":"NCT02292082","phase":"PHASE4","title":"The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2014-11","conditions":"Osteoarthritis","enrollment":111},{"nctId":"NCT02242201","phase":"PHASE4","title":"Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2014-09","conditions":"Total Hip Arthroplasty","enrollment":165},{"nctId":"NCT02223364","phase":"PHASE4","title":"Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2014-07","conditions":"Total Knee Arthroplasty","enrollment":165}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Periarticular Injection (PAI)","genericName":"Periarticular Injection (PAI)","companyName":"Hospital for Special Surgery, New York","companyId":"hospital-for-special-surgery-new-york","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Periarticular injection delivers therapeutic agents directly into the tissue surrounding a joint to reduce inflammation and pain during or after orthopedic surgery. Used for Perioperative pain management in orthopedic surgery (e.g., total knee arthroplasty, total hip arthroplasty), Postoperative analgesia and inflammation reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}