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Pentosan Polysulfate Sodium twice weekly
Pentosan polysulfate sodium is a semi-synthetic polysaccharide that reduces inflammation and may restore the glycosaminoglycan layer of the bladder epithelium.
Pentosan polysulfate sodium is a semi-synthetic polysaccharide that reduces inflammation and may restore the glycosaminoglycan layer of the bladder epithelium. Used for Interstitial cystitis/bladder pain syndrome.
At a glance
| Generic name | Pentosan Polysulfate Sodium twice weekly |
|---|---|
| Also known as | PPS twice weekly |
| Sponsor | Paradigm Biopharmaceuticals Ltd. |
| Drug class | Glycosaminoglycan layer protectant |
| Modality | Small molecule |
| Therapeutic area | Urology |
| Phase | Phase 3 |
Mechanism of action
The drug acts as an anti-inflammatory agent and is thought to coat and protect the bladder urothelium by replenishing or stabilizing the glycosaminoglycan (GAG) layer, which is often damaged in interstitial cystitis. This protective mechanism may reduce pain and urinary symptoms associated with bladder inflammation and increased permeability.
Approved indications
- Interstitial cystitis/bladder pain syndrome
Common side effects
- Gastrointestinal disturbances (nausea, diarrhea, abdominal pain)
- Headache
- Hair loss (alopecia)
- Rash
Key clinical trials
- A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain. (PHASE3)
- Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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