{"id":"pentosan-polysulfate-sodium-twice-weekly","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, diarrhea, abdominal pain)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hair loss (alopecia)"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug acts as an anti-inflammatory agent and is thought to coat and protect the bladder urothelium by replenishing or stabilizing the glycosaminoglycan (GAG) layer, which is often damaged in interstitial cystitis. This protective mechanism may reduce pain and urinary symptoms associated with bladder inflammation and increased permeability.","oneSentence":"Pentosan polysulfate sodium is a semi-synthetic polysaccharide that reduces inflammation and may restore the glycosaminoglycan layer of the bladder epithelium.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:02.027Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Interstitial cystitis/bladder pain syndrome"}]},"trialDetails":[{"nctId":"NCT06917404","phase":"PHASE3","title":"A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.","status":"RECRUITING","sponsor":"Paradigm Biopharmaceuticals Ltd.","startDate":"2025-05-29","conditions":"Osteoarthritis, Knee","enrollment":466},{"nctId":"NCT04809376","phase":"PHASE2, PHASE3","title":"Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain","status":"ACTIVE_NOT_RECRUITING","sponsor":"Paradigm Biopharmaceuticals USA (INC)","startDate":"2021-10-19","conditions":"Osteoarthritis, Knee","enrollment":602}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PPS twice weekly"],"phase":"phase_3","status":"active","brandName":"Pentosan Polysulfate Sodium twice weekly","genericName":"Pentosan Polysulfate Sodium twice weekly","companyName":"Paradigm Biopharmaceuticals Ltd.","companyId":"paradigm-biopharmaceuticals-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pentosan polysulfate sodium is a semi-synthetic polysaccharide that reduces inflammation and may restore the glycosaminoglycan layer of the bladder epithelium. Used for Interstitial cystitis/bladder pain syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}