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penile nerve block with bupivacaine
Bupivacaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief in the penile region.
Bupivacaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief in the penile region. Used for Local anesthesia for penile surgical procedures and interventions.
At a glance
| Generic name | penile nerve block with bupivacaine |
|---|---|
| Sponsor | University of Colorado, Denver |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Urology |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a local anesthetic that reversibly inhibits sodium influx into nerve cells, preventing depolarization and blocking nerve conduction. When administered as a penile nerve block, it anesthetizes the dorsal nerves of the penis and surrounding sensory nerves, providing localized pain relief without systemic effects. This allows for pain-free surgical or procedural intervention on penile tissue.
Approved indications
- Local anesthesia for penile surgical procedures and interventions
Common side effects
- Local tissue irritation or inflammation
- Temporary numbness or paresthesia
- Systemic toxicity (if absorbed in high concentrations)
Key clinical trials
- Caudal vs Dorsal Penile Nerve Block for Postoperative Analgesia in Children Undergoing Hypospadias Repair (CaD-DPNB) (NA)
- Anatomical Measurements of Pudendal Nerve Block in Children
- Sacral Erector Spinae Plane Block Versus Penile Block For Analgesia In Pediatric Circumcision (NA)
- Saddle Block With IT Morphine for Penile Inversion Vaginoplasty (NA)
- Comparison of Caudal Blockade and Dorsal Penile Nerve Block With and Without the Intravenous Administration of Dexamethasone for Analgesia After Paediatric Male Circumcision (PHASE4)
- An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision (PHASE2)
- Dorsal Nerve Block and Caudal Block in Hypospedius Repair in Children (PHASE1)
- Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants? (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |