{"id":"penile-nerve-block-with-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation or inflammation"},{"rate":null,"effect":"Temporary numbness or paresthesia"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a local anesthetic that reversibly inhibits sodium influx into nerve cells, preventing depolarization and blocking nerve conduction. When administered as a penile nerve block, it anesthetizes the dorsal nerves of the penis and surrounding sensory nerves, providing localized pain relief without systemic effects. This allows for pain-free surgical or procedural intervention on penile tissue.","oneSentence":"Bupivacaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief in the penile region.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:33:36.287Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for penile surgical procedures and interventions"}]},"trialDetails":[{"nctId":"NCT07306806","phase":"NA","title":"Caudal vs Dorsal Penile Nerve Block for Postoperative Analgesia in Children Undergoing Hypospadias Repair (CaD-DPNB)","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-09-28","conditions":"Hypospadias Repair, Pediatric Anesthesia, Postoperative Analgesia","enrollment":30},{"nctId":"NCT07348029","phase":"","title":"Anatomical Measurements of Pudendal Nerve Block in Children","status":"NOT_YET_RECRUITING","sponsor":"Istanbul University - Cerrahpasa","startDate":"2026-01-20","conditions":"Postoperative Pain Management, Penile Surgery-Related Pain","enrollment":50},{"nctId":"NCT07321717","phase":"NA","title":"Sacral Erector Spinae Plane Block Versus Penile Block For Analgesia In Pediatric Circumcision","status":"NOT_YET_RECRUITING","sponsor":"Istanbul University - Cerrahpasa","startDate":"2026-01-01","conditions":"Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia, Regional Anaesthesia","enrollment":60},{"nctId":"NCT06556121","phase":"NA","title":"Saddle Block With IT Morphine for Penile Inversion Vaginoplasty","status":"RECRUITING","sponsor":"Women's College Hospital","startDate":"2025-08-07","conditions":"Pain, Postoperative","enrollment":40},{"nctId":"NCT05598255","phase":"PHASE4","title":"Comparison of Caudal Blockade and Dorsal Penile Nerve Block With and Without the Intravenous Administration of Dexamethasone for Analgesia After Paediatric Male Circumcision","status":"TERMINATED","sponsor":"Algemeen Ziekenhuis Maria Middelares","startDate":"2022-07-01","conditions":"Analgesic Effect","enrollment":54},{"nctId":"NCT04646967","phase":"PHASE2","title":"An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision","status":"COMPLETED","sponsor":"Alberta Children's Hospital","startDate":"2022-11-25","conditions":"Pain, Postoperative, Phimosis, Paraphimosis","enrollment":100},{"nctId":"NCT06500286","phase":"PHASE1","title":"Dorsal Nerve Block and Caudal Block in Hypospedius Repair in Children","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-08","conditions":"Dorsal Nerve Block in Hypospiudus","enrollment":103},{"nctId":"NCT02861950","phase":"PHASE4","title":"Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2017-05-24","conditions":"Hypospadias, Urethrocutaneous Fistula","enrollment":165},{"nctId":"NCT06410482","phase":"NA","title":"Analgesia in Pediatric Hypospadias Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-05","conditions":"Hypospadias","enrollment":26},{"nctId":"NCT06086106","phase":"","title":"Comparison Between the Caudal Block and Other Methods of Postoperative Pain Relief in Children Undergoing Circumcision","status":"COMPLETED","sponsor":"Salmaniya Medical Complex","startDate":"2023-05-01","conditions":"Analgesia, Pain, Postoperative, Pain, Acute","enrollment":90},{"nctId":"NCT05342259","phase":"NA","title":"Low Dose Caudal VS Dorsal Penile Nerve Block for Postoperative Analgesia After Circumcision","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-05-25","conditions":"Pain, Postoperative","enrollment":81},{"nctId":"NCT05233683","phase":"PHASE3","title":"Caudal Block Versus Dorsal Penile Nerve Block Plus Ring Block for Pain Management of Different Surgical Techniques of Circumcision in Infants and Children","status":"UNKNOWN","sponsor":"King Saud University","startDate":"2022-03","conditions":"Anesthesia, Anesthesia, Local, Analgesia","enrollment":120},{"nctId":"NCT04479371","phase":"PHASE1","title":"Liposomal Bupivacaine vs Standard Penile Block for Hypospadias Repair","status":"WITHDRAWN","sponsor":"University of Texas Southwestern Medical Center","startDate":"2021-07","conditions":"Hypospadias","enrollment":""},{"nctId":"NCT04668183","phase":"","title":"Ultrasound-guided PNB and DPNB for Pediatric Distal Hypospadias Surgery","status":"COMPLETED","sponsor":"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization","startDate":"2019-11-01","conditions":"Regional Anesthesia, Hypospadias","enrollment":30},{"nctId":"NCT04215874","phase":"","title":"Caudal Epidural Block and DPNB in Hypospadias","status":"COMPLETED","sponsor":"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization","startDate":"2019-04-14","conditions":"Hypospadias, Postoperative Pain","enrollment":26},{"nctId":"NCT02973958","phase":"PHASE1","title":"Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision","status":"COMPLETED","sponsor":"Alberta Children's Hospital","startDate":"2017-02-01","conditions":"Pain, Postoperative, Phimosis, Paraphimosis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"penile nerve block with bupivacaine","genericName":"penile nerve block with bupivacaine","companyName":"University of Colorado, Denver","companyId":"university-of-colorado-denver","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine blocks sodium channels in nerve fibers to provide local anesthesia and pain relief in the penile region. Used for Local anesthesia for penile surgical procedures and interventions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}